ArticleBioactive materials2025
Dual-layer microneedles with NO/O
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A dual-index framework for cold atmospheric plasma dosing: A meta-analysis of parametric control from volumetric redox flux to redox homeostatic status.Redox biology · 2026Pooled it
- A core-shell microneedle patch coordinates early anti-inflammatory modulation and sustained pro-angiogenic stimulation for cardiac repair after myocardial infarction.Materials today. Bio · 2026Article
- Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review).Molecular medicine reports · 2026Review
- Spatiotemporal ultrasound-driven piezoelectric electro-NO therapy restores neuro-vascular-immune homeostasis for radiation ulcer repair.Materials today. Bio · 2026Article
- Targeting the neuro-immune-skin axis: Advanced functional biomaterials for intelligent wound management and regeneration.Materials today. Bio · 2026Review
- Microneedle-based platforms for wound healing: recent advances.Journal of materials chemistry. B · 2026Review
- Dual-Stage Microneedle Patch With Lipid Droplet-Mediated 'Capture-Kill' and Sustained Release for Enhanced Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Accelerated diabetic wound healing via microenvironmental modulation treated by hydrogel encapsulated with neural stem cells.Regenerative therapy · 2026Article
- A Photothermal-Responsive PRP-Loaded Hydrogel Engineered With Composite Nanobottle for Controllable Delivery of Growth Factors and Multifunctional Therapy of Diabetic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Environmentally activatable hydrogel for spatiotemporally programmed nitric oxide delivery for diabetic wound healing.Materials today. Bio · 2026Article
- Microneedle Strategies for Diabetic Wound Management: A Comprehensive Review of Materials, Mechanisms, and Therapeutic Outcomes.Materials today. Advances · 2026Article
- Ultrasound Controlled-Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS Scavenging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- NO-driven self-propelled nanomotors with deep biofilm penetration for synergistic therapy of peri-implantitis.Materials today. Bio · 2026Article
- The Quartet of Core Oncogenic Drivers in Neuroendocrine Prostate Cancer: Multi-Omics Dataset Integration to Forge a Translational Link Between Biology and Precision Therapy.International journal of biological sciences · 2026Review
- Controlled Delivery of Gasotransmitters for Cardiovascular Therapy: Molecular Mechanisms, Engineered Platforms, and Translational Perspectives.International journal of nanomedicine · 2026Review
- Dual-layer microneedles for immunomodulation and infection-responsive therapy in diabetic foot ulcers.Materials today. Bio · 2025Article
- Multifunctional Metal Composite Hydrogels for Diabetic Wound Therapy.Gels (Basel, Switzerland) · 2025Review
- NIR-controlled photothermal intelligent nanozyme synergizes catalysis and gas therapy for multidimensional treatment of inflammatory bowel disease.Journal of nanobiotechnology · 2025Article
- BMDMs in metabolic memory impair fracture healing in diabetes.Stem cell research & therapy · 2025Article
- Rocket-Like Microneedle Patch for Sustained Hormone Therapy in Prostate Cancer.ACS biomaterials science & engineering · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic wounds present multiple functional impairments, including neurovascular dysregulation, oxidative imbalance, and immune dysfunction, making wound healing particularly challenging, while traditional therapeutical strategies fail to address these complex issues effectively. Herein, we propose a strategy utilizing dual-layer microneedles to deliver therapeutic gases by modulating neurovascular coupling and immune functions for diabetic wound treatment. The microneedle can respond to reactive oxygen species (ROS) in the diabetic microenvironment and subsequently generate oxygen (O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.