ArticleNature. Mental health2024
A Meta-analysis of Loneliness and Risk of Dementia using Longitudinal Data from >600,000 Individuals.
Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Purpose in life and mortality: A meta-analysis of the published literature and individual-participant data of 488,765 participants followed for up to 32 years.Psychological medicine · 2026Pooled it
- How loneliness and social isolation are linked to cognitive decline among older adults? A systematic review of underlying physiological and psychobehavioral mechanisms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Frailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature.Journal of the American Geriatrics Society · 2026Pooled it
- Life satisfaction and risk of dementia in older adults: findings from 15 European countries and meta-analysis.Age and ageing · 2025Pooled it
- Loneliness and cognition in older adults: A meta-analysis of harmonized studies from the United States, England, India, China, South Africa, Mexico, and Chile.Psychological medicine · 2025Pooled it
- Loneliness and physical activity: Findings from an ecological momentary assessment and accelerometry study.Journal of health psychology · 2026Article
- Loneliness and Plasma Biomarkers of Neurodegeneration in Community-Dwelling Older Adults: Cross-Sectional and Longitudinal Analyses.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Public Health Policy Responses to Population Aging in Mexico: A Rights-Based and Socio-Legal Approach.Healthcare (Basel, Switzerland) · 2026Review
- "I Am Not Lonely; I Am Just No Longer Needed": Unnamed Loneliness, Masculinities, Intimacy, and Mental Health Among Older Men in Lisbon, Portugal.European journal of investigation in health, psychology and education · 2026Article
- Association between mild action tremor and cognition in community dwelling older adults: results from the KORA-Age study.Journal of neurology · 2026Article
- Midlife Vascular and Lifestyle Determinants of Late-Life Cognitive Decline and Dementia: A Life-Course Prevention Framework with a Gulf (GCC) Perspective.Life (Basel, Switzerland) · 2026Review
- Prevalence of social disconnection in the general adult population - results from DISCONNECT study.Social psychiatry and psychiatric epidemiology · 2026Article
- Review
- Socio-emotional well-being is associated with cognitive function and informant-rated cognitive decline: Results from the Harmonized Cognitive Assessment Protocol in Europe.Journal of the International Neuropsychological Society : JINS · 2026Article
- Meaning in life and Parkinson's disease: Evidence from a 17-year study across 14 countries.Archives of gerontology and geriatrics · 2026Article
- Joint association of postoperative visual acuity status and baseline loneliness with cognitive impairment after cataract surgery in older adults: a retrospective cohort study.Frontiers in medicine · 2026Article
- Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns.EXCLI journal · 2026Review
- Clinical relevance of loneliness in the treatment of depression: study protocol for a naturalistic prospective longitudinal study.Frontiers in psychiatry · 2026Article
- Toward a transdiagnostic modifier for clinically significant loneliness in psychiatry: a conceptual mini review.Frontiers in psychiatry · 2026Review
- Hearing loss and loneliness in the development of impaired cognition and dementia in the US All of Us cohort: prospective analyses using electronic health records.BMJ public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Loneliness is one critical risk factor for cognitive health. Combining data from ongoing aging studies and the published literature, we provided the largest meta-analysis on the association between loneliness and dementia (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.