ArticleJournal of pathology informatics2025
A standards-based application for improving platelet transfusion workflow.
Article in Journal of pathology informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
20 authors.
Funding
Abstract
Objective: Thrombocytopenia is a common complication of hematopoietic stem-cell transplantation (HSCT), though many patients will become immune refractory to platelet transfusions over time. We built and evaluated an electronic health record (EHR)-integrated, standards-based application that enables blood-bank clinicians to match platelet inventory with patients using data previously not available at the point-of-care, like human leukocyte antigen (HLA) data for donors and recipients. Materials and methods: The web-based application launches as an EHR-embedded application or as a standalone application. The application coalesces disparate data streams into a unified view, including platelet count, HLA data, demographics, and real-time inventory. We looked at application usage over time and developed a multivariable logistic regression model to compute odds ratios that a patient undergoing HSCT would have a complicated thrombocytopenia course, with several model covariates including pre-/post-application deployment. Results: Usage of the application has been consistent since launch, with a slight dip during the first COVID wave. Our model, which included 376 patients in the final analysis, did not demonstrate a significantly decreased odds that a patient would have a complicated thrombocytopenia course after application deployment as compared to before application deployment. Discussion: We built an EHR-integrated application to improve platelet transfusion processes. Whereas our model did not demonstrate decreased odds of a patient having a complicated thrombocytopenia course, there are other workflow and clinical benefits that will benefit from future evaluation. Conclusion: A web-based, EHR-integrated application was built and integrated into our EHR system and is now part of the standard operating procedures of our blood bank.
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