ArticleOncology letters2025
Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Advancing Cancer Cachexia Drug Development: Leveraging Biomarkers and Functional Endpoints to Optimize Trial Design.Cancer reports (Hoboken, N.J.) · 2026Review
- Global Research Trends in Nutritional Management of Gastrointestinal Cancers: a 2004-2024 Bibliometric and knowledge-mapping Analysis.Journal of gastrointestinal cancer · 2026Review
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Authors and funding
20 authors.
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Abstract
Cancer cachexia is a complex disorder characterized by skeletal muscle loss, which may influence the prognosis of patients with cancer. The cachexia index (CXI) is a new index for cachexia. The present study aimed to assess whether the CXI determined by bioelectrical impedance analysis (BIA) is valuable for predicting survival in patients with gastrointestinal cancer. A total of 54 patients with gastrointestinal cancer undergoing BIA at the time of diagnosis at Fukuchiyama City Hospital (Kyoto, Japan) were retrospectively recruited. CXI values were calculated as follows: CXI=skeletal muscle index (SMI) × serum albumin concentration/neutrophil-to-lymphocyte ratio. The SMI was measured using BIA values. The patients were classified into low- and high-CXI groups. The median patient age was 72 years and 63.0% of patients were male. A total of 20 patients with colorectal cancer were enrolled, 12 with pancreatic cancer, 11 with gastric cancer, 6 with esophageal cancer, 4 with biliary tract cancer and 1 with liver cancer. The cumulative one-year overall survival (OS) rate was significantly worse in the low-CXI group compared with that in the high-CXI group (58.3 vs. 88.5%; P=0.012). By contrast, the SMI had no significant effect on OS. Thus, CXI values using BIA may predict survival in patients with gastrointestinal cancer.
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