Evidence map›Paper›PMID 39802176›Full record

ArticleJournal of molecular and cellular cardiology plus2023

Genetic deletion of 12/15 lipoxygenase delays vascular remodeling and limits cardiorenal dysfunction after pressure overload.

Dae Hyun Lee, Vasundhara Kain, Da-Zhi Wang, Donald G Rokosh, Sumanth D Prabhu, Ganesh V Halade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Comprehensive Plasma Oxylipin Profiling Reveals a Pro-Inflammatory Eicosanoid Signature and Diagnostic Biomarker Panel in Dilated Cardiomyopathy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dae Hyun LeeDivision of Cardiovascular Disease, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Florida 33602, United States.
Vasundhara KainDivision of Cardiovascular Disease, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Florida 33602, United States.
Da-Zhi WangDivision of Cardiovascular Disease, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Florida 33602, United States.
Donald G RokoshCardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, MO 63110, United States.
Sumanth D PrabhuCardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, MO 63110, United States.
Ganesh V HaladeDivision of Cardiovascular Disease, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Florida 33602, United States.

Funding

Resolution of Inflammation in Heart Failure Post-Myocardial InfarctionR01HL132989 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2016 to 2020
$1.8M
Lipoxygenase Signaling in Heart Failure PathologyR01HL144788 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL132989NHLBI NIH HHS R01 HL144788
6 · The paper itself

Abstract

The lipid metabolizing enzyme 12/15 lipoxygenase (12/15LOX) induces proinflammatory responses that may increase cardiovascular and renal complications after cardiac insult. To define the role of 12/15LOX, 8-12-week-old male C57BL/6J wild-type (WT;

Indexed as

Heart failureInflammation-resolution signalingLipid mediatorsLipoxygenasePressure overloadTransverse aortic constriction

Identifiers

PMID39802176
PMCPMC11708313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.