ArticleHeliyon2025
Emerging trends and new developments in global research on artemisinin and its derivatives.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Protective role ofFrontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The World Health Organization recommends the use of artemisinin (ART) and its derivatives for malaria treatment. Furthermore, these compounds exhibit encouraging pharmacological effects for the treatment of several diseases. Nevertheless, ongoing antimalarial treatment efforts have been significantly hindered by the emergence of drug resistance. A systematic evaluation and analysis of relevant studies may yield insights to help resolve this dilemma and reveal options for future research. Purpose: The objective of this study was to provide researchers with a comprehensive synopsis of the advancements made in the study of ART and its significant derivatives, as well as to visually present the data and provide insightful observations that can inform subsequent investigations in this domain. Methods: We searched the Web of Science Core Collection for relevant studies published by December 31, 2023. The research hotspots and frontiers pertinent to this field in terms of countries, institutions, authors, journals, references, and keywords were ascertained through scientometric analysis via CiteSpace software. Results: This study included an extensive assemblage of 12,985 data points, and the findings suggest that ART and its derivatives have garnered considerable interest among scientists. Prolonged international collaboration has fostered progress in this research field. "Antimalarials," "synthesis," "drug resistance," and " Conclusion: This study offers a comprehensive compendium of the developments and trends in the relevant research field over the past fifty years. Since pharmaceutical drug synthesis can influence both drug efficacy and cost-effectiveness, ongoing efforts to improve drug synthesis are warranted. Although the advent of novel therapeutic approaches has partially mitigated drug resistance, further investigations into the underlying mechanisms are needed. While better treatments for malaria have been developed, the therapeutic potential of ART and its derivatives for numerous additional important diseases is also possible, and future research in this area can lead to dramatic improvements in health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.