Evidence map›Paper›PMID 39801599›Full record

ArticleObesity pillars2025

Significantly higher rates of KIDINS220 polymorphisms in patients with obesity and end-stage renal disease.

Jesse Richards, Madisen Fae Dorand, Maria Paszkowiak, Sana Ahmed, Courtney McCorkle, Pranay Kathuria

Abstract read
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Article in Obesity pillars, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jesse RichardsDepartment of Internal Medicine, University of Oklahoma School of Community Medicine, 4502 E. 41st Street, Tulsa, OK, 74135, USA.
Madisen Fae DorandDepartment of Internal Medicine, University of Oklahoma School of Community Medicine, 4502 E. 41st Street, Tulsa, OK, 74135, USA.
Maria PaszkowiakCollege of Medicine, University of Oklahoma School of Community Medicine, 4502 E. 41st Street, Tulsa, OK, 74135, USA.
Sana AhmedCollege of Medicine, University of Oklahoma School of Community Medicine, 4502 E. 41st Street, Tulsa, OK, 74135, USA.
Courtney McCorkleCollege of Medicine, University of Oklahoma School of Community Medicine, 4502 E. 41st Street, Tulsa, OK, 74135, USA.
Pranay KathuriaDepartment of Nephrology, University of Oklahoma School of Community Medicine, 4502 E. 41st Street, Tulsa, OK, 74135, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Kinase D-interacting substrate of 220 kDa ("KIDINS220") is an integral plasma membrane protein essential to signaling throughout the body; abnormalities are linked to a variety of disorders, including obesity, but have never been directly linked to chronic- or end-stage renal disease. Methods: Retrospective chart review identified patients with severe obesity who presented for pre-kidney transplant weight management. 20 individuals met criteria for testing for genetic causes of obesity. A χ Results: This case series presents a cohort of patients with severe obesity and end-stage renal disease who were subsequently found to have a significantly higher rate of KIDINS220 mutations (20 %, χ Conclusions: Mutations within KIDINS220 may play a modulatory role in the progression of chronic kidney disease in patients with obesity, as evidenced by this small retrospective study. The relationship between KIDINS200, kidney disease, and obesity is complex and requires further study, but may represent a potential therapeutic target in the future.

Indexed as

Clinical geneticsKidney diseaseNephrologyTransplant

Identifiers

PMID39801599
PMCPMC11719405

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