Evidence map›Paper›PMID 39801594›Full record

ArticleChina CDC weekly2024

Coal Worker's Pneumoconiosis-Targeted Lipidomics Reveals Aberrant Phospholipid Metabolism for Early-Stage Diagnosis.

Yuzhen Feng, Jing Dai, Junyun Wang, Fangda Peng, Wenrong Wang, Xiao Yu, Xiaomei Kong, Qingjun Qian, Qicai Liu, Huanqiang Wang and 2 more

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Article in China CDC weekly, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yuzhen FengGuangdong Pharmaceutical University, Guangzhou City, Guangdong Province, China.
Jing DaiNational Center for Occupational Safety and Health, NHC, Beijing, China.
Junyun WangNational Center for Occupational Safety and Health, NHC, Beijing, China.
Fangda PengNational Center for Occupational Safety and Health, NHC, Beijing, China.
Wenrong WangNational Center for Occupational Safety and Health, NHC, Beijing, China.
Xiao YuNHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Key Laboratory of Respiratory Diseases, The First Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, China.
Xiaomei KongNHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Key Laboratory of Respiratory Diseases, The First Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, China.
Qingjun QianNational Center for Occupational Safety and Health, NHC, Beijing, China.
Qicai LiuNational Center for Occupational Safety and Health, NHC, Beijing, China.
Huanqiang WangNational Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China.
Chunguang DingGuangdong Pharmaceutical University, Guangzhou City, Guangdong Province, China.
Yiwei ShiNHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Key Laboratory of Respiratory Diseases, The First Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pneumoconiosis is the most prevalent occupational disease in China, with coal worker pneumoconiosis (CWP) demonstrating the highest incidence. Studies have indicated that phospholipids may be associated with CWP. Methods: In this study, serum was obtained from 62 patients with pneumoconiosis, 105 coal dust-exposed workers, and 50 healthy individuals and analyzed via targeted lipidomics using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). After initially identifying phospholipids with significant differences through univariate and multivariate statistical analyses, receiver operating characteristic (ROC) analysis was performed. The differential phospholipids identified in patient samples were then integrated to assess their diagnostic potential for CWP using a support vector machine (SVM). Results: Compared with healthy subjects, the levels of Lyso-PS (18:0) were decreased, while PC (16:0), PC (18:0), PC (16:0/18:1), PI (16:0/18:1), PS (18:1), PG (16:0), and PG (18:0/18:1) were significantly increased in the pneumoconiosis group, with an area under the curve (AUC)>0.7. Moreover, compared with the dust-exposed group, Lyso-PC (16:0), PC (16:0), PC (16:0/18:1), PI (16:0/18:1), and PG (16:0) were significantly elevated in the pneumoconiosis group, with an AUC>0.7. The diagnostic model, including PC (16:0), PC (16:0/18:1), PI (16:0/18:1), and PG (16:0), demonstrated excellent performance with an AUC of 0.956. Discussion: The serum phospholipid profiles of patients with pneumoconiosis differed significantly from those of controls, including differences in PC, Lyso-PC, PI, PS, Lyso-PS, and PG. Among these, a diagnostic model incorporating PC (16:0), PC (16:0/18:1), PI (16:0/18:1), and PG (16:0) demonstrated superior screening efficiency.

Indexed as

BiomarkersCoal worker pneumoconiosisPhospholipidsTargeted lipidomics

Identifiers

PMID39801594
PMCPMC11718381

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