SynthesisAmerican journal of hypertension2025
Impact of Daytime and Nighttime Blood Pressure and Nocturnal Blood Pressure Fall on Heart Failure Risk in Treated Hypertension.
Synthesis in American journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of morning or evening antihypertensive therapy on heart failure in community resident patients: Results of the TIME and BedMed Trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- Nighttime blood pressure levels and phenotypes: prognostic value and reproducibility.American journal of hypertension · 2026Article
- Antihypertensive therapy tailored to the circadian blood pressure profile as precision medicine.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Response to Comment on: Effect of morning or evening antihypertensive therapy on heart failure in community resident patients: results of the TIME and BedMed trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Evening vs. morning antihypertensives: impact on heart failure risk.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The insulin resistance-systemic vascular resistance-isolated diastolic hypertension axis: a metabolic framework for an overlooked hypertension phenotype.Frontiers in cardiovascular medicine · 2026Review
- Association between nocturnal blood pressure dipping patterns and left atrial reservoir strain in untreated adults with office-defined grade 1 essential hypertension.Frontiers in cardiovascular medicine · 2026Article
- Supine hypertension and cardiovascular disease: controversies and advances.Future cardiology · 2025Review
- Which Systolic Blood Pressure Measure Is Most Important for Determining Cardiovascular Risk: Seated or Supine Blood Pressure?Current hypertension reports · 2025Review
- Nighttime Blood Pressure Matters Even in Heart Failure.Journal of the American Heart Association · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundTo evaluate the impact of daytime, nighttime, and nocturnal blood pressures (BPs) fall on heart failure (HF).
methodsWe analyzed data from five cohorts including 15,526 treated hypertensive patients, experiencing 625 HF events, by study-level meta-analysis. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for 1SD increase in BP parameters or per group were calculated.
resultsWhen individually analyzed after adjustment for covariates, clinic systolic BP (SBP) (HR 1.20, 95% CI 1.01-1.43), daytime SBP (HR 1.34, 95% CI 1.06-1.70), nighttime SBP (HR 1.43, 95% CI 1.20-1.71), nighttime diastolic BP (DBP) (HR 1.26, 95% CI 1.05-1.52), % of nocturnal SBP fall (HR 0.81, 95% CI 0.75-0.88), and nondipping (HR 1.64, 95% CI 1.54-1.98) were associated with HF. If daytime or nighttime BP was further adjusted for clinic BP results remained similar. When clinic, daytime, and nighttime BPs were mutually adjusted, nighttime SBP (HR 1.43, 95% CI 1.27-1.61) and nighttime DBP (HR 1.37, 95% CI 1.14-1.64) remained associated with the outcome. Heterogeneity across cohorts was explained by BP, sex, and follow-up duration. In sensitivity analyses, for daytime and nighttime BPs, no study had a relevant influential effect on overall estimates. Looking for publication bias and adjusting for missing studies by Duval and Tweedie's method, clinic SBP lost significance but daytime SBP, and nighttime SBP and DBP remained significantly associated with HF.
conclusionsDaytime and nighttime BPs are stronger than clinic BP in predicting HF, nighttime BP is stronger than daytime BP, and a reduced nocturnal BP fall is associated with outcome.
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