Evidence map›Paper›PMID 39801122›Full record

ArticleGlobal spine journal2025

A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population.

Mark A MacLean, Antoinette J Charles, Miltiadis Georgiopoulos, Jackie Phinney, Raphaële Charest-Morin, Rory Goodwin, Ilya Laufer, Michael G Fehlings, John Shin, Nicholas Dea and 13 more

Abstract read
In one paragraph

Article in Global spine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Cellular and molecular mechanisms of fatty infiltration in paraspinal muscles in spine-specific sarcopenia.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mark A MacLeanDivision of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0002-8535-0776
Antoinette J CharlesSpine Division, Department of Neurosurgery, Duke University, Durham, NC, USA.
Miltiadis GeorgiopoulosSpine Surgery Program, Department of Surgery, McGill University, Montreal, QC, Canada.ORCID 0000-0001-8656-1412
Jackie PhinneyW.K Kellogg Health Sciences Library, Saint John, NB, Canada.ORCID 0000-0002-2044-7358
Raphaële Charest-MorinSpine Surgery Institute, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-7689-1087
Rory GoodwinSpine Division, Department of Neurosurgery, Duke University, Durham, NC, USA.ORCID 0000-0002-6540-2751
Ilya LauferDepartment of Neurosurgery, New York University Langone Health, New York, NY, USA.
Michael G FehlingsDivision of Neurosurgery and Spine Program, Department of Surgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-5722-6364
John ShinDepartment of Neurosurgery, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Nicholas DeaSpine Surgery Institute, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.
Laurence D RhinesDivision of Surgery, Department of Neurosurgery, The University of Texas MD Anderson Cancer Centre, Houston, TX, USA.
Arjun SahgalSunnybrook Health Sciences Centre, Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Ziya GokaslanDepartment of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Byron StephensDepartment of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Alexander C DischUniversity Center for Orthopedics, Trauma & Plastic Surgery, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany.
Naresh KumarDepartment of Orthopedic Surgery, National University Health System, Singapore.ORCID 0000-0003-4538-5031
John O'TooleDepartment of Neurosurgery, Rush University, Chicago, IL, USA.
Daniel M SciubbaDepartment of Neurosurgery, Zucker School of Medicine at Hofstra, Long Island Jewish Medical Center and North Shore University Hospital, Northwell Health, Manhasset, NY, USA.
Cordula NetzerDepartment of Spine Surgery, University Hospital of Basel, Basel, Switzerland.
Tony GoldschlagerDepartment of Surgery, Monash University, Melbourne, VIC, Australia.ORCID 0000-0001-9572-0227
Wende GibbsDepartment of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, USA.
Michael H WeberSpine Surgery Program, Department of Surgery, McGill University, Montreal, QC, Canada.
AO Spine Knowledge Forum Tumor

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designSystematic review and clinimetric analysis.

objectivesFrailty and sarcopenia predict worse surgical outcomes among spinal degenerative and deformity-related populations; this association is less clear in the context of spinal oncology. Here, we sought to identify frailty and sarcopenia tools applied in spinal oncology and appraise their clinimetric properties.

methodsA systematic review was conducted from January 1

resultsTwenty-two studies were included (42 514 patients). Seventeen studies utilized 6 frailty tools; the three most employed were the Metastatic Spine tumor Frailty Index (MSTFI), Modified Frailty Index-11 (mFI-11), and the mFI-5. Eight studies utilized measures of sarcopenia; the three most common were the L3-Total Psoas Area (TPA)/Vertebral Body Area (VBA), L3-TPA/Height

conclusionsExisting tools for evaluating frailty and sarcopenia among patients undergoing surgery for spinal tumors have poor clinimetric properties. Here, we provide a pragmatic approach to utilizing existing frailty and sarcopenia tools, until more clinimetrically robust instruments are developed.

Indexed as

diseasefrailtymetastaticsarcopeniaspinetumor

Identifiers

PMID39801122
PMCPMC11988247

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.