Evidence map›Paper›PMID 39801121›Full record

ArticleGlobal spine journal2025

Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know.

Hanbo Chen, Amol J Ghia, Pejman J Maralani, Chetan Bettegowda, Stefano Boriani, Nicolas Dea, Charles G Fisher, Alessandro Gasbarrini, Ziya L Gokaslan, Ilya Laufer and 5 more

Abstract read
In one paragraph

Article in Global spine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hanbo ChenDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.ORCID 0000-0002-6447-653X
Amol J GhiaDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Pejman J MaralaniDepartment of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stefano BorianiDepartment of Spine Surgery, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Nicolas DeaCombined Neurosurgical and Orthopaedic Spine Program, University of British Columbia, Vancouver, BC, Canada.
Charles G FisherCombined Neurosurgical and Orthopaedic Spine Program, University of British Columbia, Vancouver, BC, Canada.
Alessandro GasbarriniDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Ziya L GokaslanDepartment of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Ilya LauferDepartment of Neurological Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Aron LazaryNational Center for Spinal Disorders, Budapest, Hungary.ORCID 0000-0002-0157-719X
Jeremy ReynoldsOxford Spinal Surgery Unit, Oxford University Hospitals, Oxford, UK.
Jorrit-Jan VerlaanDepartment of Orthopaedic Surgery, University of Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands.
Laurence D RhinesDivision of Surgery, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designNarrative review of existing literature.

objectivesSignificant technological advancements in radiotherapy planning and delivery have enabled new radiotherapy techniques for the management of spine tumors. The objective of this study was to provide a comprehensive summary of these treatment techniques for practicing spine surgeons.

methodsA narrative review of the existing literature on stereotactic body radiation therapy (SBRT) and particle beam therapy (PBT) for the treatment of spine tumors was performed. The characteristics, implementation and evidence supporting these strategies in the management of primary spinal neoplasms were summarized.

resultsThe clinical effectiveness of SBRT for the control and symptom palliation of metastatic spinal tumors are well demonstrated in multiple clinical trials. Risks such as fracture, radiculopathy and plexopathy exist after spine SBRT, necessitating an individualized approach in a well experienced multidisciplinary setting. SBRT should be considered a key component of a well-rounded treatment plan for metastatic spine tumors in combination with surgery, vertebral augmentation, and drug therapy, where indicated, to achieve optimal patient outcomes. Additionally, PBT and SBRT are also leading to promising results for primary spine tumors, though comparative effectiveness studies and prospective clinical trials are required to establish these modalities more formally as alternatives to conventionally fractionated photon radiotherapy.

conclusionsSBRT and PBT are emerging as effective and well tolerated treatment options for primary and metastatic spine tumors. Additional investigation is needed to personalize these treatment options and further strengthen these approaches as key components in a multidisciplinary approach to the management of spinal neoplasms.

Indexed as

metastasesoncologyradiationtumorvertebral body fracture

Identifiers

PMID39801121
PMCPMC11726527

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.