Evidence map›Paper›PMID 39801118›Full record

ArticleGlobal spine journal2025

Defining Spine Cancer Pain Syndromes: A Systematic Review and Proposed Terminology.

Markian Pahuta, Ilya Laufer, Sheng-Fu Larry Lo, Stefano Boriani, Charles Fisher, Nicolas Dea, Michael H Weber, Dean Chou, Arjun Sahgal, Laurence Rhines and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global spine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Markian PahutaDepartment of Orthopaedic Surgery, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-4808-5459
Ilya LauferDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY, USA.
Sheng-Fu Larry LoDepartment of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.
Stefano BorianiDepartment of Ageing, Neurosciences, Head-Neck and Orthopaedics Sciences, IRCCS Istituto Ortopedico Galeazzi, Bologna, Italy.
Charles FisherDepartment of Orthopaedics, The University of British Columbia, Vancouver, BC, Canada.
Nicolas DeaDepartment of Orthopaedics, The University of British Columbia, Vancouver, BC, Canada.
Michael H WeberDepartment of Orthopedics, McGill University, Montreal, QC, Canada.
Dean ChouDepartment of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Science Center, Toronto, ON, Canada.
Laurence RhinesDepartment of Neurosurgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-8474-1521
Jeremy ReynoldsDepartment of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Oxford, UK.ORCID 0000-0002-1632-139X
Aron LazaryDepartment of Spine Surgery at Semmelweis University, National Center for Spinal Disorders, Budapest, Hungary.ORCID 0000-0002-0157-719X
Alessandro GasbarrinniDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Jorrit-Jan VerlaanDepartment of Orthopaedics, UMC Utrecht, Utrecht, The Netherlands.
Ziya GokaslanDepartment of Spine, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Chetan BettegowdaDepartment of Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mohamed SarrajDepartment of Orthopaedic Surgery, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-3879-0445
Ori BarzilaiDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4037-8716
AO Spine Knowledge Forum Tumor

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

STUDY

designSystematic Review.

objectivesFormalized terminology for pain experienced by spine cancer patients is lacking. The common descriptors of spine cancer pain as mechanical or non-mechanical is not exhaustive. Misdiagnosed spinal pain may lead to ineffective treatment recommendations for cancer patients.

methodsWe conducted a systematic review of pain terminology that may be relevant to spinal oncology patients. We provide a comprehensive and unbiased summary of the existing evidence, not limited to the spine surgery literature, and subsequently consolidate these data into a practical, clinically relevant nomenclature for spine oncologists.

resultsOur literature search identified 3515 unique citations. Through title and abstract screening, 3407 citations were excluded, resulting in 54 full-text citations for review. Pain in cancer patients is typically described as nociceptive pain (somatic vs visceral), neurologic pain and treatment related pain.

conclusionsWe consolidate the terminology used in the literature and consolidated into clinically relevant nomenclature of biologic tumor pain, mechanical pain, radicular pain, neuropathic pain, and treatment related pain. This review helps standardize terminology for cancer-related pain which may help clinicians identify pain generators.

Indexed as

pain syndromespinal metastasis

Identifiers

PMID39801118
PMCPMC11726517

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.