Evidence map›Paper›PMID 39801114›Full record

ArticleGlobal spine journal2025

Liquid Biopsy for Spinal Tumors: On the Frontiers of Clinical Application.

Sze Kiat Tan, Chetan Bettegowda, Stephen Yip, Arjun Sahgal, Laurence Rhines, Jeremy Reynolds, Aron Lazary, Ilya Laufer, Alessandro Gasbarrini, Nicolas Dea and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global spine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sze Kiat TanDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9653-555X
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stephen YipDepartment of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Odette Cancer Center, Toronto, ON, Canada.
Laurence RhinesDepartment of Neurosurgery, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Jeremy ReynoldsOxford Spinal Unit, Oxford University, Oxford, UK.
Aron LazaryDepartment of Spine Surgery, Semmelweis University, Budapest, Hungary.
Ilya LauferDepartment of Neurosurgery at NYU Grossman School of Medicine, New York, NY, USA.
Alessandro GasbarriniDepartment of Orthopedic Surgery, Rizzoli Institute, University of Bologna, Bologna, Italy.
Nicolas DeaCombined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada.
J J VerlaanDepartment of Orthopedic Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.
Ziya L GokaslanDepartment of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Charles G FisherCombined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada.
Stefano BorianiGSpine4, IRCCS Galeazzi-Sant'Ambrogio Hospital, Milan, Italy.
Riccardo CecchinatoGSpine4, IRCCS Galeazzi-Sant'Ambrogio Hospital, Milan, Italy.
Matthew L GoodwinDepartment of Orthopedic Surgery, Washington University in St Louis, St Louis, MO, USA.
C Rory GoodwinDepartment of Neurosurgery, Spine Division, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-6540-2751
Raphaële Charest-MorinCombined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-7689-1087

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designNarrative review.

objectivesThis article aims to provide a narrative review of the current state of research for liquid biopsy in spinal tumors and to discuss the potential application of liquid biopsy in the clinical management of patients with spinal tumors.

methodsA comprehensive review of the literature was performed using PubMed, Google Scholar, Medline, Embase and Cochrane databases, and the review was limited to articles of English language. All the relevant articles which were identified to be related to liquid biomarker study in spinal tumors, were studied in full text.

resultsLiquid biopsy has revolutionized the field of precision medicine by guiding personalized clinical management of cancer patients based on the liquid biomarker status. In recent years, more research has been done to investigate its potential utilization in patients with tumors from the spine. Herein, we review the liquid biomarkers that have been proposed in different spine malignancies including chordoma, chondrosarcoma, Ewing sarcoma, osteosarcoma, astrocytoma and ependymoma. We also discuss the wide window of opportunity to utilize these liquid biomarkers in diagnosis, treatment response, monitoring, and detection of minimal residual disease in patients with spinal tumors.

conclusionsLiquid biomarkers, especially blood-derived circulating tumor DNA, has a promising clinical utility as they are disease-specific, minimally invasive, and the procedure is repeatable. Prospective studies with larger populations are needed to fully establish its use in the setting of spinal tumors.

Indexed as

blood biomarkerscerebrospinal fluid biomarkerchondrosarcomachordomacirculating tumor DNAependymomaEwing sarcomaliquid biopsyosteosarcomaspinal tumors

Identifiers

PMID39801114
PMCPMC11726521

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.