Evidence map›Paper›PMID 39801105›Full record

ArticleBiometrics2025

Causal inference with cross-temporal design.

Yi Cao, Pedro L Gozalo, Roee Gutman

Abstract read
In one paragraph

Article in Biometrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yi CaoDepartment of Clinical Development and Analytics, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, United States.ORCID 0000-0003-4708-8954
Pedro L GozaloDepartment of Health Services, Policy and Practice, Brown University, Providence, RI 02903, United States.
Roee GutmanDepartment of Biostatistics, Brown University, Providence, RI 02903, United States.ORCID 0000-0001-7095-3016

Funding

VARIATIONS IN LIFE'S FINAL CHAPTERP01AG027296 · NIA · BROWN UNIVERSITY · PI AMAL N. TRIVEDI · 2007 to 2026
$38.9M
NIA NIH HHS P01 AG027296NIH HHS P01AG027296U.S. National Institute on Aging
6 · The paper itself

Abstract

When many participants in a randomized trial do not comply with their assigned intervention, the randomized encouragement design is a possible solution. In this design, the causal effects of the intervention can be estimated among participants who would have experienced the intervention if encouraged. For many policy interventions, encouragements cannot be randomized and investigators need to rely on observational data. To address this, we propose a cross-temporal design, which uses time to mimic a randomized encouragement experiment. However, time may be confounded with temporal trends that influence the outcomes. To disentangle these trends from the intervention effects, we replace the commonly used exclusion restrictions with temporal assumptions. We develop Bayesian procedures to estimate the causal effects and compare it to instrumental variables and matching approaches in simulations. The Bayesian approach outperforms the other 2 approaches in terms of estimation accuracy, and it is relatively robust to various violations of the common trends assumption. Taking advantage of the expansion of the Medicare Advantage (MA) program between 2011 and 2017, we implement the proposed method to estimate the effects of MA enrollment on the risk of skilled nursing facility residents being re-hospitalized within 30 days after discharge from the hospital.

Indexed as

BiometryCausalityRandomized Controlled Trials as TopicBayes TheoremComputer SimulationHumansModels, StatisticalResearch DesignTime FactorsUnited Statesdata augmentationencouragement designinstrumental variableobservational study

Identifiers

PMID39801105
PMCPMC11725568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.