Evidence map›Paper›PMID 39801102›Full record

ArticleJournal of oral & facial pain and headache2024

Therapeutic potential of trazodone in trigeminal neuralgia based on inflammation and oxidative stress: an

Jun Yang, Junling Huang, Zhimin Pan, Xiao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral & facial pain and headache, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jun Yang *Department of Geriatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 310003 Hangzhou, Zhejiang, China.
Junling Huang *Department of Geriatrics, Tongji Hospital, School of Medicine Tongji University, 200065 Shanghai, China.
Zhimin PanDepartment of Geriatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 310003 Hangzhou, Zhejiang, China.
Xiao WangDepartment of Geriatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 310003 Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trigeminal neuralgia (TN) is a debilitating condition affecting the patients' life quality. New therapeutic approaches and novel drugs are required to treat TN. Trazodone being a serotonin antagonist and reuptake inhibitor (SARI) provides neuroprotection, however its role and underlying mechanism in TN

Indexed as

InflammationOxidative StressSelective Serotonin Reuptake InhibitorsTrazodoneTrigeminal NeuralgiaAnimalsCell LineCell ProliferationInterleukin-1betaInterleukin-6LipopolysaccharidesMiceNeurogliaReactive Oxygen SpeciesTumor Necrosis Factor-alphaInterleukin-1betaInterleukin-6LipopolysaccharidesReactive Oxygen SpeciesSelective Serotonin Reuptake InhibitorsTrazodoneTumor Necrosis Factor-alphaInflammationMAPK pathwayOxidative stressTrazodoneTrigeminal neuralgia (TN)

Identifiers

PMID39801102
PMCPMC11810673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.