ArticleTurkish journal of pharmaceutical sciences2025
Influence of Formulation Composition on the Characteristic Properties of 5-fluorouracil-loaded Liposomes.
Article in Turkish journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Exploring intracellular anti-mycobacterium activity of lactoferricin-loaded niosomes: proteomics insights into Immunomodulation.Scientific reports · 2025Article
- Assessment of the Anti-Acne Properties of Some Medicinal Plants and Development of an Herbal Anti-Acne Formulation.Pharmaceutics · 2025Article
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Authors and funding
2 authors.
Funding
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Abstract
Objectives: Variations in the types and quantities of excipients used to prepare liposomes can affect the physicochemical properties of liposome formulations. This study aimed to provide information about the design and fabrication of 5-fluorouracil (5-FU)-loaded liposome formulations using different lipid and cholesterol (CHOL) derivatives. Materials and Methods: Passive loading via a small-volume incubation method was used to prepare liposomes. The particle size, polydispersity index, zeta potential, and encapsulation efficiency (EE%) of the formulations were determined. The release studies of the formulations were conducted using a Franz diffusion cell at 37 °C. In this study, a high-pressure liquid chromatography device was used to measure the amount of 5-FU. Results: The mean particle sizes of all formulations were between 134 and 166 nm, and they had a negative charge on their surface. Increasing the cholesteryl hemisuccinate content reduced the size of the liposomes. Additionally, all formulations exhibited a low polydispersity index (0.3). The EE% of all formulations exceeded 30%. The Conclusion: Modifying the lipid and CHOL content in the formulations, as indicated by the experimental results, can change the characteristic properties of liposomes. The use of soybean phosphatidylcholine and cholesteryl hemisuccinate appears to be a promising combination for the preparation of hydrophilic drug-loaded liposome formulations.
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