ArticleTurkish journal of pharmaceutical sciences2025
Isolation of the Major Compounds and Determination of Biological Activities in the Underground Parts of
Article in Turkish journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Lipid Metabolism-Related Enzyme Inhibition and Antioxidant Potential of the Extracts and Phytochemical Compounds from Trachystemon orientalis (L.) D.Don.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Article
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8 authors.
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Abstract
Objectives: Materials and Methods: Isolation studies were carried out on the subextracts (the chloroform, ethyl acetate and remaining aqueous) prepared from the methanol extract of TOU using various chromatographic methods, and the structures of the purified compounds were determined by 1D-NMR, 2D-NMR, and mass spectroscopy techniques. To determine antioxidant activity, ferric-reducing antioxidant power (FRAP) and Cu(II) ion-reducing antioxidant capacity (CUPRAC) assays were performed. Lipase inhibitory activity was determined using an Results: In the isolation studies, rosmarinic acid (1) was isolated from the ethyl acetate subextract and danshensu (2), globoidnan B (3), and rabdosiin (4) were isolated from the remaining aqueous subextract. These compounds were isolated from TOU for the first time. The ethyl acetate subextract had higher activity than the other extracts in the FRAP and CUPRAC assays (794.818 ± 8.999, 583.06 ± 5.882 μM Trolox equivalents (TE)/g), respectively] and rosmarinic acid exhibited the highest activity [1260.273 ± 4.499, 608.250 ± 1.195 μM TE/g, respectively). Lipase enzyme inhibitory studies showed that the remaining aqueous and ethyl acetate subextracts had significant inhibitory activity [half maximal inhibitory concentration (IC Conclusion: According to the results of this study,
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