ArticleTurkish journal of pharmaceutical sciences2025
Impact of Simulated Gastrointestinal Fluid: Viscosity, Surface Tension, and pH on the Dissolution and Rheology Assessment of Viscosity of Two Commercial Candesartan Cilexetil Products.
Article in Turkish journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: The aim of this study was to ivnestigate the effect of simulated gastrointestinal viscosity, surface tension, and pH on the dissolution rate of two commercial candesartan cilexetil (CC) products. Materials and Methods: Results: The CC dissolution rate was highest in the USP medium. It was found that the media type affected CC dissolution. The non-USP media exhibited a slower dissolution rate than the USP specification. The highest viscosity media lowered the dissolution rate in one of the CC products. Acidic pH showed a significant decrease in dissolution for both CC products. The solubility of CC was affected by solvent type (p value < 0.001). Conclusion: Higher viscosity media slow the dissolution rate of a product, where a gel layer forms on the tablet surface.The results show variation in the dissolution media. This may reveal differences in the dissolution rates of the same drug in different products and media. Considering, viscosity's effect on dissolution might improve patient outcomes when treated with different products.
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