Evidence map›Paper›PMID 39801001›Full record

ArticleTurkish journal of pharmaceutical sciences2025

Binoy Varghese Cheriyan, Punithavel Srinivasan, Georgepush Jayaraj, Karthik Kadhiri Karunakar, Prasanna Bharathi Sainath, Anandakumar Shanmugam, Anitha Roy, Karthikeyan Elumalai

Abstract read
In one paragraph

Article in Turkish journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Binoy Varghese CheriyanSaveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha College of Pharmacy, Department of Pharmaceutical Chemistry, Tamil Nadu, India.ORCID 0000-0003-0830-6816
Punithavel SrinivasanSaveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha College of Pharmacy, Department of Pharmaceutical Chemistry, Tamil Nadu, India.ORCID 0009-0003-6129-0451
Georgepush JayarajSaveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha College of Pharmacy, Department of Pharmaceutical Chemistry, Tamil Nadu, India.ORCID 0009-0009-5277-8328
Karthik Kadhiri KarunakarSaveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha College of Pharmacy, Department of Pharmacology, Tamil Nadu, India.ORCID 0009-0003-2944-6655
Prasanna Bharathi SainathSaveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha College of Pharmacy, Department of Pharmacology, Tamil Nadu, India.ORCID 0000-0002-4179-7744
Anandakumar ShanmugamUniversity of Madras, Dr. ALM Post Graduate Institute of Basic Medical Science, Department of Microbiology, Tamil Nadu, India.ORCID 0000-0003-3306-7589
Anitha RoySaveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Department of Pharmacology, Tamil Nadu, India.ORCID 0000-0002-8631-0936
Karthikeyan ElumalaiSaveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha College of Pharmacy, Department of Pharmaceutical Chemistry, Tamil Nadu, India.ORCID 0000-0002-6259-5332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The present study aimed to assess the antiproliferative and pro-apoptotic effects of hinokitiol in osteosarcoma cells Materials and Methods: The (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to evaluate the cytotoxic potential of hinokitiol in osteosarcoma cells. Various concentrations of hinokitiol (5, 10, 20, 40, 60, and 80 μg/mL) were tested, and the half-maximal inhibitory concentration (IC Results: Hinokitiol significantly ( Conclusion: According to the current study findings, hinokitiol prevented Morphological study of the effects of hinokitiol on osteosarcoma cells from proliferating, migrating, and induced apoptosis by upregulating BAX (a pro-apoptotic signal) expression and downregulating BCL-2 (anti-apoptotic signal) expression in osteosarcoma cells.

Indexed as

glycogen synthase kinase 3βHinokitiolin silicoMTT assayosteosarcoma

Identifiers

PMID39801001
PMCPMC11730009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.