ArticleTurkish journal of pharmaceutical sciences2025
Initial Empirical Antibiotic Treatment in Patients with COVID-19 is Associated with Excess Adverse Drug Reactions without Clinical Benefit.
Article in Turkish journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Objectives: Empirical antibiotic use is common among hospitalized patients with coronavirus disease-2019 (COVID-19) pneumonia because it is difficult to differentiate it from concurrent bacterial pneumonia. The aim of this study was to determine risk factors for concurrent bacterial community-acquired pneumonia (b-CAP) and the need for initial empirical antibiotic coverage in patients with pulmonary involvement caused by Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) infection. Materials and Methods: This prospective observational study was conducted at a tertiary university hospital between March 2020 and April 2021. Patients aged over 18 years who were hospitalized due to COVID-19 were included. Risk factors and outcomes were compared between patients who initially received empirical antibiotics and those who did not. Results: The presence of respiratory viral pathogens other than SARS-CoV-2 was investigated Conclusion: Initial empirical antibiotic treatment is common among patients infected with SARS-CoV-2, although the coinfection rate is low. Empirical antibiotic(s) did not improve the clinical course in COVID-19 patients.
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