Evidence map›Paper›PMID 39800807›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Impact of Tafamidis on [

An-Li Yu, Yi-Chieh Chen, Cheng-Hsuan Tsai, Chi-Chao Chao, Mao-Yuan Su, Chia-Tung Shun, Hsueh-Wen Hsueh, Jyh-Ming Jimmy Juang, Ming-Jen Lee, Ping-Huei Tseng and 3 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. QuantitativeAsia Oceania journal of nuclear medicine & biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

An-Li YuDepartment of Internal Medicine, Division of Cardiology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.
Yi-Chieh ChenDepartment of Nuclear Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei, 100, Taiwan.
Cheng-Hsuan TsaiDepartment of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Chi-Chao ChaoDepartment of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Mao-Yuan SuDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Tung ShunDepartment of Forensic Medicine and Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Hsueh-Wen HsuehDepartment of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Jyh-Ming Jimmy JuangDepartment of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Ming-Jen LeeDepartment of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Ping-Huei TsengDepartment of Internal Medicine, Division of Gastroenterology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Sung-Tsang HsiehDepartment of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Mei-Fang Cheng *Department of Nuclear Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei, 100, Taiwan. meifang@ntuh.gov.tw.ORCID 0000-0002-9359-0606
Yen-Hung Lin *Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. austinr34@gmail.com.

Funding

Pfizer Pfizer
6 · The paper itself

Abstract

objectiveTafamidis has shown potential in slowing disease progression in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). This study aimed to evaluate serial changes on [

methodsWe retrospectively analyzed a prospectively collected cohort of Ala97Ser (A97S) hereditary ATTR-CM patients treated with tafamidis (61 mg/day) and a control group comprising A97S hereditary ATTR-CM patients who had not received disease-modifying medications. The tafamidis group was further divided into two cohorts: cohort A received [

resultsNineteen patients were enrolled in the tafamidis group and nine in the control group. After 2 years of follow-up, a significant decrease in volumetric H/L ratio (3.86 ± 0.91 to 3.01 ± 0.19, p < 0.001) was noted in the tafamidis group, while there was no significant change in the control group. When evaluated over time, a significant decrease in volumetric H/L ratio was observed during the first year of tafamidis treatment (3.75 ± 0.37 to 2.82 ± 0.15, p = 0.004), followed by stable [

conclusionA significant reduction in [

Indexed as

Amyloid Neuropathies, FamilialBenzoxazolesCardiomyopathiesTechnetium Tc 99m PyrophosphateAgedFemaleHumansMaleMiddle AgedRadiopharmaceuticalsRetrospective StudiesSingle Photon Emission Computed Tomography Computed TomographyTime FactorsTreatment OutcomeBenzoxazolesRadiopharmaceuticalstafamidisTechnetium Tc 99m Pyrophosphate[99mTc]Tc-pyrophosphate single-photon emission computed tomography/Computed tomographyHeart failureHereditary transthyretin amyloidosisTafamidis

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.