Evidence map›Paper›PMID 39800780›Full record

ReviewCell death discovery2025

New insights into constitutive neutrophil death.

Tong Chen, Qian Ren, Fengxia Ma

Abstract readReview
In one paragraph

Review in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Autophagy: a double-edged sword in ischemia-reperfusion injury.Cellular & molecular biology letters · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tong ChenState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, 300020, China.ORCID http://orcid.org/0000-0003-1711-3186
Qian RenState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, 300020, China.
Fengxia MaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, 300020, China. mafengxia@ihcams.ac.cn.ORCID http://orcid.org/0000-0003-2678-0407

Funding

Chinese Academy of Medical Sciences (CAMS) 2021-I2M-1-040Chinese Academy of Medical Sciences (CAMS) 2022-I2M-JB-015National Natural Science Foundation of China (National Science Foundation of China) 82171756Natural Science Foundation of Tianjin City (Natural Science Foundation of Tianjin) 22JCYBJC01120
6 · The paper itself

Abstract

Neutrophils undergo rapid aging and death known as constitutive or spontaneous death. Constitutive neutrophil death (CND) contributes to neutrophil homeostasis and inflammation resolution. CND has long been considered to be apoptotic until our findings reveal that it was a heterogeneous combination of diverse death. Furthermore, dead neutrophils retain functional roles via multiple manners. This review provides an overview of current research on the mechanism and modulation of CND. More noteworthy, we also summarize the after-death events of neutrophils. The fate of neutrophils can be changed under pathological conditions, so the involvement of CND in diseases and CND-related therapeutic strategies are also addressed.

Identifiers

PMID39800780
PMCPMC11725587

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.