Evidence map›Paper›PMID 39800698›Full record

ArticleCritical care (London, England)2025

Revisiting the oxygen reactivity index in traumatic brain injury: the complementary value of combined focal and global autoregulation monitoring.

Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Ihsane Olakorede, Xuhang Chen, Adel Helmy, Andrea Lavinio, Peter J Hutchinson, Peter Smielewski

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Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Teodor Svedung WettervikDepartment of Medical Sciences, Section of Neurosurgery, Uppsala University, 751 85, Uppsala, Sweden. teodor.svedung-wettervik@neuro.uu.se.
Erta BeqiriBrain Physics Laboratory, Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge, UK.
Anders HånellDepartment of Medical Sciences, Section of Neurosurgery, Uppsala University, 751 85, Uppsala, Sweden.
Stefan Yu BögliBrain Physics Laboratory, Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge, UK.
Ihsane OlakoredeBrain Physics Laboratory, Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge, UK.
Xuhang ChenBrain Physics Laboratory, Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge, UK.
Adel HelmyDepartment of Clinical Neurosciences, Division of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Andrea LavinioNeurosciences and Trauma Critical Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK.
Peter J HutchinsonDepartment of Clinical Neurosciences, Division of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Peter SmielewskiBrain Physics Laboratory, Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge, UK.

Funding

Medical Research Council MR N013433-1Swiss National Science Foundation 210839
6 · The paper itself

Abstract

backgroundThe oxygen reactivity index (ORx) reflects the correlation between focal brain tissue oxygen (pbtO

methods425 TBI patients with intracranial pressure (ICP)- and pbtO

resultsGAMs showed that ORx increased with higher ICP, PRx above + 0.30, CPP below 60-70 mmHg, and negative ΔCPPopt. In contrast to PRx, ORx did not increase at higher CPP. In outcome heatmaps, there was a transition towards unfavourable outcome when ORx exceeded + 0.50, particularly for longer durations, and in combination with high ICP, high PRx, low CPP, negative ΔCPPopt, and low pbtO

conclusionsORx seemed to be sensitive to the lower, but not the upper, limit of autoregulation, in contrast to PRx which was sensitive to both. The combination of high values for both ORx and PRx was particularly associated with worse outcome and, thus, ORx may provide a complementary value to the global index PRx. ORx could also be useful to determine the safe and dangerous perfusion target intervals.

Indexed as

Brain Injuries, TraumaticHomeostasisOxygenAdultAgedCerebrovascular CirculationCohort StudiesFemaleGlasgow Outcome ScaleHumansIntracranial PressureLogistic ModelsMaleMiddle AgedMonitoring, PhysiologicRetrospective StudiesOxygenBrain tissue oxygenationOxygen reactivity indexPressure reactivity indexTraumatic brain injury

Identifiers

PMID39800698
PMCPMC11725216

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