Evidence map›Paper›PMID 39800460›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

Maintaining level of modifiable dementia risk scores is associated with better cognitive outcomes than increasing risk scores: A population-based prospective cohort study.

Stephanie Van Asbroeck, Md Hamidul Huque, Scherazad Kootar, Ruth Peters, Nicolas Cherbuin, Moyra E Mortby, Sebastian Köhler, Martin Pj van Boxtel, Kay Deckers, Kaarin J Anstey

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In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephanie Van AsbroeckAlzheimer Center Limburg, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, P.O. Box 616 6200 MD Maastricht, Netherlands.
Md Hamidul HuqueSchool of Psychology, University of New South Wales, Sydney, NSW 2057, Australia; Neuroscience Research Australia, Margarete Ainsworth Building, 139 Barker St, Randwick NSW 2031, Australia.
Scherazad KootarSchool of Psychology, University of New South Wales, Sydney, NSW 2057, Australia; Neuroscience Research Australia, Margarete Ainsworth Building, 139 Barker St, Randwick NSW 2031, Australia; Clinical Research Centre, The Children's Hospital, Westmead, NSW 2145, Australia.
Ruth PetersThe George Institute for Global Health, Level 18, International Towers 3, 300 Barangaroo Ave, Sydney NSW 2000 Australia; School of Population Health, University of New South Wales, Sydney, NSW 2052, Australia; School of Public Health, Imperial College London, London SW7 2AZ, United Kingdom.
Nicolas CherbuinCentre for Research on Ageing, Health and Wellbeing, 54 Mills Road, Acton, Canberra ACT 2601 Australia.
Moyra E MortbySchool of Psychology, University of New South Wales, Sydney, NSW 2057, Australia; Neuroscience Research Australia, Margarete Ainsworth Building, 139 Barker St, Randwick NSW 2031, Australia.
Sebastian KöhlerAlzheimer Center Limburg, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, P.O. Box 616 6200 MD Maastricht, Netherlands.
Martin Pj van BoxtelAlzheimer Center Limburg, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, P.O. Box 616 6200 MD Maastricht, Netherlands.
Kay DeckersAlzheimer Center Limburg, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, P.O. Box 616 6200 MD Maastricht, Netherlands.
Kaarin J AnsteySchool of Psychology, University of New South Wales, Sydney, NSW 2057, Australia; Neuroscience Research Australia, Margarete Ainsworth Building, 139 Barker St, Randwick NSW 2031, Australia. Electronic address: k.anstey@unsw.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA brain healthy lifestyle, consisting of good cardiometabolic health and being cognitively and socially active in midlife, is associated with a lower risk of cognitive decline years later. However, it is unclear whether lifestyle changes over time also affect the risk for mild cognitive impairment (MCI)/dementia, and rate of cognitive decline.

objectivesTo investigate if lifestyle changes over time are associated with incident MCI/dementia risk and rate of cognitive decline.

designPopulation-based prospective cohort study

settingPersonality and Total Health (PATH) Through Life Study cohort (Australia).

participants4,777 participants (50.4% women), recruited between 2000 and 2002, who were 40-44 and 60-64 years old at baseline, without a prevalent dementia diagnosis. Participants had to have cognitive outcome measures available after baseline. MEASUREMENTS: Various measurements (neurocognitive assessment, blood pressure) and survey responses (demographics, cognitive, social, and physical activity, smoking, alcohol consumption, body height and weight, depression, and previous diagnoses) were collected approximately every four years. A brain-healthy lifestyle was operationalized via two well-validated modifiable dementia risk scores, the LIfestyle for BRAin health (LIBRA) score and the modifiable part of the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI

resultsWithin those aged 60-64 years at baseline (n=2,409), 211 cases of incident MCI/dementia were recorded over a median follow-up time of 12.2 years. On average, individuals' LIBRA and ANU-ADRI

conclusionsEfforts to maintain a brain healthy lifestyle could reduce the risk for MCI or dementia, and slow cognitive decline.

Indexed as

CognitionCognitive DysfunctionDementiaHealthy LifestyleLife StyleAdultAustraliaFemaleHumansMaleMiddle AgedNeuropsychological TestsProspective StudiesRisk FactorsCognitionDementiaHealth promotionLifestyleTrajectories

Identifiers

PMID39800460
PMCPMC12183925

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.