Evidence map›Paper›PMID 39800459›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

Informal care for people with dementia in Europe.

Ron Handels, Somboon Hataiyusuk, Anders Wimo, Anders Sköldunger, Christian Bakker, Anja Bieber, Alfonso Ciccone, Carlo Alberto Defanti, Andrea Fabbo, Sara Fascendini and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Ron HandelsAlzheimer Centre Limburg, Faculty of Health Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Department of Psychiatry and Neuropsychology, Maastricht University, Universiteitssingel 40, 6200 MD, Maastricht, The Netherlands; Division of Neurogeriatrics, Department of Neurobiology Care Sciences and Society; Karolinska Institutet; Sweden; BioClinicum J9:20, Akademiska stråket, 171 64 Solna, Sweden. Electronic address: ron.handels@maastrichtuniversity.nl.
Somboon HataiyusukAlzheimer Centre Limburg, Faculty of Health Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Department of Psychiatry and Neuropsychology, Maastricht University, Universiteitssingel 40, 6200 MD, Maastricht, The Netherlands; Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, 10700 Bangkok, Thailand.
Anders WimoDivision of Neurogeriatrics, Department of Neurobiology Care Sciences and Society; Karolinska Institutet; Sweden; BioClinicum J9:20, Akademiska stråket, 171 64 Solna, Sweden.
Anders SköldungerDivision of Neurogeriatrics, Department of Neurobiology Care Sciences and Society; Karolinska Institutet; Sweden; BioClinicum J9:20, Akademiska stråket, 171 64 Solna, Sweden.
Christian BakkerDepartment of Primary and Community Care, Radboud university medical center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands; Radboudumc Alzheimer Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands; Groenhuysen, Center for Geriatric Care, Bovendonk 29, 4707 ZH Roosendaal, the Netherlands.
Anja BieberInstitute of Health and Nursing Sciences, Martin Luther University Halle-Wittenberg, 06108 Halle (Saale), Germany.
Alfonso CicconeDepartment of Neurology with Neurosurgical Activity "Carlo Poma" Hospital, ASST di Mantova, Str. Lago Paiolo, 10, 46100 Mantova, MN, Italy.
Carlo Alberto DefantiCognitive Disorders and Dementia Unit, Health Authority and Services (AUSL) of Modena, Strada Minutara Hangar 3, 41122 Modena, Italy.
Andrea FabboCognitive Disorders and Dementia Unit, Health Authority and Services (AUSL) of Modena, Strada Minutara Hangar 3, 41122 Modena, Italy.
Sara FascendiniFERB Alzheimer Centre, Ospedale Briolini, via A, Manzoni, 130, 24025 Gazzaniga, Italy.
Lutz FrölichDepartment of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J 5 68159 Mannheim, Germany.
Chloé Gervès-PinquiéHealth Economics & Outcomes Research (HEOR) unit, Real World Evidence (RWE) department, IQVIA, 17 bis Tsse, des Reflets, 92400 Courbevoie, France.
Manuel Gonçalves-PereiraNOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa; CHRC, REAL Associate Laboratory, Campo dos Mártires da Pátria 130, 1169-056 Lisboa, Portugal.
Kate IrvingSchool of Nursing and Human Sciences, Dublin City University, Collins Ave Ext, Whitehall, Dublin, Ireland.
Raymond KoopmansDepartment of Primary and Community Care, Radboud university medical center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands; Radboudumc Alzheimer Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands; Joachim en Anna, center for specialized geriatric care, Groesbeekseweg 327, 6523 PA Nijmegen, the Netherlands.
Patrizia MecocciDivision of Neurogeriatrics, Department of Neurobiology Care Sciences and Society; Karolinska Institutet; Sweden; BioClinicum J9:20, Akademiska stråket, 171 64 Solna, Sweden; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, Division of Clinical Geriatrics, University of Perugia, Piazza dell'Università 1, 06123 Perugia, PG, Italy.
Paola MerloDept. of Neurology, Humanitas Gavazzeni, Via Mauro Gavazzeni 21, 24125 Bergamo, Italy.
Bernhard MichalowskyGerman Center for Neurodegenerative Diseases (DZNE), Patient-reported Outcomes & Health Economics Research, Ellernholzstraße 1, 17489 Greifswald, Germany.
Oliver PetersCharité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Charitéplatz 1, 10117 Berlin, Germany.
Yolande PijnenburgAlzheimer Center Amsterdam, Neurology department, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands; Amsterdam Neuroscience, Neurodegeneration, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Óscar RibeiroCINTESIS@RISE, Department of Education and Psychology, University of Aveiro - Campus, Universidade de Aveiro, 3810-193 Aveiro, Portugal; Universitario de Santiago, Edf 5, 3810‑193 Aveiro, Portugal.
Geir SalbaekNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Halfdan Wilhelmsens alle 17, 3103 Tønsberg, Norway; Department of Geriatric Medicine, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Problemveien 11, 0313 Oslo, Norway.
Larissa SchwarzkopfIFT Institut für Therapieforschung, Mental Health and Addiction Research, Leopoldstrasse 175, 80804 Munich, Germany; Institute for Medical Information Processing, Biometry and Epidemiology, LMU Munich, Marchioninistrasse 17, 80336 Munich, Germany.
Hilde VerbeekDepartment of Health Services Research, Care and Public Health Research Institute, Faculty of Health Medicine and Life Sciences, Maastricht University, Duboisdomein 30, 6229 GT Maastricht, the Netherlands.
Marjolein de VugtAlzheimer Centre Limburg, Faculty of Health Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Department of Psychiatry and Neuropsychology, Maastricht University, Universiteitssingel 40, 6200 MD, Maastricht, The Netherlands.
Bob WoodsDementia Services Development Centre Wales, Bangor University, Bangor LL57 2DG, UK.
Orazio ZanettiIRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni, 4, 25125 Brescia, BS, Italy.
Bengt WinbladDivision of Neurogeriatrics, Department of Neurobiology Care Sciences and Society; Karolinska Institutet; Sweden; BioClinicum J9:20, Akademiska stråket, 171 64 Solna, Sweden.
Linus JönssonDivision of Neurogeriatrics, Department of Neurobiology Care Sciences and Society; Karolinska Institutet; Sweden; BioClinicum J9:20, Akademiska stråket, 171 64 Solna, Sweden.
Actifcare consortium, ICTUS/DSA group, PLASA/DSA group, RECAGE consortium, RightTimePlaceCare consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInformal care estimates for use in health-economic models are lacking. We aimed to estimate the association between informal care time and dementia symptoms across Europe.

methodsA secondary analysis was performed on 13,529 observations in 5,369 persons from 9 European pooled cohort or trial studies in community-dwelling persons with dementia. A mixed regression model was fitted to time spent on instrumental or basic activities of daily living using disease severity and demographic characteristics.

resultsDaily informal care time was 0.5 hours higher in moderate compared to mild and 1.3h higher in severe compared to mild cognitive impairment. Likewise, this was 1.2h and 2.7h for functional disability and 0.3h and 0.6h for behavioral symptoms in the same directions. DISCUSSION: Estimates can be used in both single- and multi-domain health-economic models for dementia in European settings.

Indexed as

Activities of Daily LivingCaregiversDementiaPatient CareAgedAged, 80 and overCognitive DysfunctionEuropeFemaleHumansIndependent LivingMaleSeverity of Illness IndexTime FactorscostsDementiahealth-economic evaluationinformal careresource use

Identifiers

PMID39800459
PMCPMC12183986

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.