Evidence map›Paper›PMID 39800455›Full record

Observational studyThe journal of prevention of Alzheimer's disease2025

Motor abilities and cognitive performance in Latinos with autosomal dominant Alzheimer's disease.

Andrew J Petkus, Anup N Sonti, Lucy Montoya, Abhay Sagare, John M Ringman

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew J PetkusDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: petkus@usc.edu.
Anup N SontiDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lucy MontoyaDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center at the Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Abhay SagareZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
John M RingmanDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center at the Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
NIA NIH HHS P30 AG066530
6 · The paper itself

Abstract

backgroundDeclining motor abilities might be a noninvasive biomarker for Alzheimer's disease (AD). Studying motor ability and AD progression in younger Latinos with autosomal dominant Alzheimer's disease (ADAD) can provide insights into the interplay between motor ability and cognition in individuals with minimal confounding from age-normative changes and comorbid medical conditions.

objectivesThis study aimed to (1) examine motor abilities as a function of years to dementia diagnosis and (2) examine associations between motor ability and cognitive performance.

designThis was a cross-sectional observational study.

settingThe study took place at the University of Southern California.

participants39 predominately Latino individuals (mean age 38.6 ± 10 years old) known to carry (carriers; n=25) or be at 50% risk for inheriting ADAD but not carrying the mutation (noncarriers; n=14). MEASUREMENTS: Individuals completed the motor and cognitive batteries from the National Institute of Health Toolbox (NIHTB) and the Cognitive Abilities Screening Instrument (CASI). All models included effects for age, education, primary language, and sex.

resultsCompared to noncarriers, ADAD mutation carriers had significantly weaker grip strength at 12 years, worse manual dexterity at 10 years, and slower gait speed seven years before the expected age of dementia diagnosis. Worse motor ability was associated with a more severe cognitive disease stage and worse CASI performance, adjusting for demographic and clinical variables.

conclusionsThe findings support the utility of motor performance, precisely grip strength, manual dexterity, and gait speed as potential biomarkers of preclinical AD.

Indexed as

Alzheimer DiseaseCognitionHispanic or LatinoMotor SkillsAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsAutosomal dominant Alzheimer's diseaseCognitionLatino'sMotor function

Identifiers

PMID39800455
PMCPMC12184005

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.