ArticleOpen heart2025
Evaluation of three diagnostic algorithms to reduce normal scan rates, radiation exposure and costs in patients with suspected chronic coronary syndrome referred for 82Rb-Positron Emission Tomography (
Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe majority of functional ischemia tests in patients with suspected chronic coronary syndromes (CCS) yield normal results. Implementing gatekeepers for patient preselection, such as pretest probability (PTP) and/or coronary artery calcium score (CACS), could reduce the number of normal scan results, radiation exposure and costs. However, the efficacy and safety of these approaches remain unclear.
methodsThree diagnostic algorithms based on PTP, as summarised in the 2019 European Society of Cardiology (ESC) CCS guidelines, were retrospectively applied to 1792 patients with suspected CCS referred for 82Rb-Positron Emission Tomography (
resultsThe mean age of the patients was 65±11 years, and 43% were female. PTP ≤5% and <15% were present in 7.5% and 41.0%, respectively. Algorithm 1 reduced scans, radiation and costs by 7.5% without significantly missing ischemia (sensitivity/negative predictive value (NPV) 98.6%/99.7%). Algorithm 2 showed the largest reduction (41.0%), but sensitivity was significantly reduced (80.2%). Algorithm 3 demonstrated optimal performance, reducing radiation by 17.0% and costs by 17.3% without significantly missing ischemia suggesting excellent safety (sensitivity/NPV 98.0%/99.5%).
conclusionUsing a diagnostic algorithm combining PTP and CACS (algorithm 3), the number of normal scan results, radiation exposure and costs could be significantly reduced without a significant increase in missed diagnoses suggesting similar outcome and excellent patients safety. Consequently, this approach could help to optimally allocate limited healthcare resources while maintaining patient's safety.
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