Evidence map›Paper›PMID 39800404›Full record

ArticleBMJ open2025

Comparison of carbon dioxide control during pressure controlled versus pressure-regulated volume controlled ventilation in children (CoCO2): protocol for a pilot digital randomised controlled trial in a quaternary paediatric intensive care unit.

Rebeca Mozun, Daphné Chopard, Florian Zapf, Philipp Baumann, Barbara Brotschi, Anika Adam, Vera Jaeggi, Beat Bangerter, Kristen S Gibbons, Juerg Burren and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05843123 (Comparison of Carbon Dioxide Control During Pressure Controlled), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05843123 phase4completednot on this map

Comparison of Carbon Dioxide Control During Pressure Controlled (PC) Versus Pressure Regulated Volume Control (PRVC) Ventilation in Children (CoCO2): a Digital, Randomized Controlled Trial

TypeinterventionalSponsorUniversity Children's Hospital, ZurichRan2024 to 2024Enrolled59ConditionsRespiratory FailureArmsRespiratory support a, Respiratory support b
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rebeca MozunDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland rebeca.mozuntorrico@kispi.uzh.ch.ORCID http://orcid.org/0000-0002-5237-8668
Daphné ChopardDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Florian ZapfDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Philipp BaumannDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1244-8131
Barbara BrotschiDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Anika AdamDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Vera JaeggiData Intelligence and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Beat BangerterData Intelligence and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Kristen S GibbonsChildren's Intensive Care Research Program, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-5679-0932
Juerg BurrenDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
Luregn J SchlapbachDepartment of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDigital trials are a promising strategy to increase the evidence base for common interventions and may convey considerable efficiency benefits in trial conduct. Although paediatric intensive care units (PICUs) are rich in routine electronic data, highly pragmatic digital trials in this field remain scarce. There are unmet evidence needs for optimal mechanical ventilation modes in paediatric intensive care. We aim to test the feasibility of a digital PICU trial comparing two modes of invasive mechanical ventilation using carbon dioxide (CO METHODS AND ANALYSIS: Single-centre, open-labelled, randomised controlled pilot trial with two parallel treatment arms comparing pressure control versus pressure-regulated volume control. Patients are eligible if aged <18 years, weighing >2 kg, have an arterial line and require >60 min of mechanical ventilation during PICU hospitalisation at the University Children's Hospital Zurich. Exclusion criteria include cardiac shunt lesions, pulmonary hypertension under treatment and intracranial hypertension. CO ETHICS AND DISSEMINATION: This study received ethical approval from the Cantonal Ethics Commission of Zurich (identification number: 2022-00829). Study results will be disseminated through publication in a peer-reviewed journal and other media like podcasts. TRIAL REGISTRATION NUMBER: NCT05843123.

Indexed as

Carbon DioxideIntensive Care Units, PediatricRespiration, ArtificialAdolescentBlood Gas AnalysisChildChild, PreschoolFemaleHumansInfantMalePilot ProjectsPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicCarbon DioxideElectronic Health RecordsPaediatric intensive & critical carePAEDIATRICSRandomised Controlled Trial

Identifiers

PMID39800404
PMCPMC11752026

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.