Evidence map›Paper›PMID 39799695›Full record

ArticleBiomaterials2025

Cartilaginous microtissues exhibit extreme resilience under compression with size-dependent mechanical properties.

Charalampos Androulidakis, Hanna Svitina, Konstantinos Ioannidis, Alexander R Dunn, Ioannis Papantoniou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charalampos AndroulidakisPrometheus Division of Skeletal Tissue Engineering, KU Leuven, O&N1, Herestraat 49, PB 813, 3000, Leuven, Belgium; Skeletal Biology and Engineering Research, KU Leuven, ON1 Herestraat 49, PB 813, 3000, Leuven, Belgium; Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
Hanna SvitinaPrometheus Division of Skeletal Tissue Engineering, KU Leuven, O&N1, Herestraat 49, PB 813, 3000, Leuven, Belgium; Skeletal Biology and Engineering Research, KU Leuven, ON1 Herestraat 49, PB 813, 3000, Leuven, Belgium.
Konstantinos IoannidisPrometheus Division of Skeletal Tissue Engineering, KU Leuven, O&N1, Herestraat 49, PB 813, 3000, Leuven, Belgium; Skeletal Biology and Engineering Research, KU Leuven, ON1 Herestraat 49, PB 813, 3000, Leuven, Belgium.
Alexander R DunnDepartment of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
Ioannis PapantoniouPrometheus Division of Skeletal Tissue Engineering, KU Leuven, O&N1, Herestraat 49, PB 813, 3000, Leuven, Belgium; Skeletal Biology and Engineering Research, KU Leuven, ON1 Herestraat 49, PB 813, 3000, Leuven, Belgium. Electronic address: ioannis.papantoniou@kuleuven.be.

Funding

Molecular mechanisms underlying force transduction at cellular adhesion complexesR35GM130332 · NIGMS · STANFORD UNIVERSITY · PI Alexander R Dunn · 2019 to 2026
$4.9M
NIGMS NIH HHS R35 GM130332
6 · The paper itself

Abstract

Self-assembled cartilaginous microtissues provide a promising means of repairing challenging skeletal defects and connective tissues. However, despite their considerable promise in tissue engineering, the mechanical response of these engineered microtissues is not well understood. Here we examine the mechanical and viscoelastic response of progenitor cell aggregates formed from human primary periosteal cells and the resulting cartilaginous microtissues under large deformations as might be encountered in vivo. We find that the mechanical response of these tissues is strongly size dependent due to surface tension effects, with a scaling law for the Young's modulus of E ∝ D

Indexed as

CartilageBiomechanical PhenomenaCells, CulturedCompressive StrengthElastic ModulusHumansPeriosteumStem CellsStress, MechanicalSurface TensionTissue EngineeringViscosity

Identifiers

PMID39799695
PMCPMC11850221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.