Evidence map›Paper›PMID 39799666›Full record

ArticleJournal of psychiatric research2025

Social functioning and frontal alpha asymmetry in schizophrenia.

Emily A Farina, Michal Assaf, Silvia Corbera, Jimmy Choi, Christine Yantz, Chi-Ming Chen

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Article in Journal of psychiatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Emily A FarinaYale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, USA; Department of Psychological Sciences, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT, USA. Electronic address: Emily.Farina@yale.edu.
Michal AssafOlin Neuropsychiatric Research Center, Hartford Hospital, 400 Washington Street, Hartford, CT, USA.
Silvia CorberaDepartment of Psychological Science, Central Connecticut State University, New Britain, CT, USA.
Jimmy ChoiOlin Neuropsychiatric Research Center, Hartford Hospital, 400 Washington Street, Hartford, CT, USA.
Christine YantzDepartment of Psychological Sciences, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT, USA.
Chi-Ming ChenDepartment of Psychological Sciences, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT, USA.

Funding

The Social Brain in Schizophrenia and Autism Spectrum DisordersR01MH095888 · NIMH · HARTFORD HOSPITAL · PI ASSAF, MICHAL · 2012 to 2016
$2.6M
NIMH NIH HHS R01 MH095888
6 · The paper itself

Abstract

backgroundSchizophrenia (SZ) is a psychiatric disorder that often involves reduced social functioning. Frontal alpha asymmetry (FAA) is a neurophysiological marker extracted from electroencephalogram (EEG) data that is likely related to motivational and emotional tendencies, such as reduced motivation across various psychiatric disorders, including SZ. Therefore, it may offer a neurophysiological marker for social functioning.

objectivesThe present study aimed to examine whether FAA is related to social functioning in schizophrenia. Additionally, a group of people with autism spectrum disorder (ASD) was included to explore whether findings are unique to schizophrenia, or whether they are found in another diagnostic group with atypical social behaviors.

methodsAnalysis of variance and regression models were used to evaluate data from resting-state EEG, clinical interviews, and self-report measures. Data from 33 participants with SZ were compared to 38 healthy controls and 30 individuals with ASD.

resultsAlthough people with SZ showed differences in FAA compared to healthy controls, the altered neurophysiology was not related to reduced social functioning in SZ. However, FAA was related to social functioning in people without a psychiatric diagnosis. Additionally, comparisons between the SZ and ASD group revealed few differences in patterns of FAA and social functioning, suggesting commonalities between the disorders in these areas.

conclusionsFAA likely does not present a neurophysiological marker for reduced social functioning in schizophrenia, though future work should examine its role in other possible clinical manifestations shared between schizophrenia and ASD.

Indexed as

Alpha RhythmAutism Spectrum DisorderFrontal LobeSchizophreniaSocial BehaviorAdultElectroencephalographyFemaleHumansMaleMiddle AgedYoung AdultAutism spectrum disorderElectroencephalogramFrontal alpha asymmetrySchizophreniaSocial functioning

Identifiers

PMID39799666
PMCPMC11830537

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