ArticleArchives of toxicology2025
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4).
Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Octamethylcyclotetrasiloxane (D4) lacks endocrine disruptive potential via estrogen pathways.Archives of toxicology · 2025Article
- Alteration of pituitary and hypothalamic membrane fluidity as a non-specific mode-of-action for reproductive effects with octamethylcyclotetrasiloxane.EXCLI journal · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetically-derived maximal dose (KMD) is defined as the maximum external dose at which kinetics are unchanged relative to lower doses, e.g., doses at which kinetic processes are not saturated. Toxicity produced at doses above the KMD can be qualitatively different from toxicity produced at lower doses. Here, we test the hypothesis that high-dose-dependent toxicological effects of octamethylcyclotetrasiloxane (D4) occur secondary to kinetic overload. Octamethylcyclotetrasiloxane (D4) is a volatile, highly lipophilic monomer used to produce silicone polymers, which are ingredients in many consumer products and used widely in industrial applications and processes. Chronic inhalation at D4 concentrations 10
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