ArticleJournal of periodontal research2025
High-Frequency Ultrasound for Detecting Periodontal Inflammation: A Preclinical Diagnostic Accuracy Study.
Article in Journal of periodontal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Ultrasound-based assessment of peri-implant mucosal thickness: an ex vivo comparative study with artificial intelligence-assisted image analysis.BMC oral health · 2026Article
- Accuracy and bias of high-frequency ultrasonography in measuring white spot lesion depth: an in-vitro comparison with micro-CT.Clinical oral investigations · 2026Article
- Digital Dental Radiology and Diagnostics-From 2D to 3D.Australian dental journal · 2025Review
- Performance Evaluation of a Miniaturized, Toothbrush-Shaped Ultrasound Transducer for Periodontal Imaging.ACS sensors · 2025Article
- Clinical-oriented 3D visualization and quantitative analysis of gingival thickness using convolutional neural networks and CBCT.Frontiers in dental medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
aimUltrasonography (US) has shown accuracy in imaging healthy periodontium. This study aims to evaluate the feasibility and accuracy of US for estimating dimensions of inflamed periodontium induced by ligature and bacteria.
methodsPeriodontal tissues of maxillary as well as mandibular premolars and molars in six female mini pigs were treated with ligature and three strains of bacteria for 4-10 weeks. Before euthanization, the periodontium was imaged with US. After euthanization, cone-beam computed tomography (CBCT) scans and histology were performed. Soft and hard tissue measurements by calibrated and masked examiners from US, CBCT, and histology were statistically compared.
resultsSeventy-one histological samples with corresponding CBCT and US scans were available for analysis. Overall, there was a good to excellent agreement between histology and US (ICC: 0.77-0.96) for parameters such as Soft Tissue Thickness (STT), Gingival Recession, Crestal Bone Thickness (CBT), and the bone-to-cemento-enamel junction (B-CEJ) distance. However, discrepancies were observed for STT at 3 mm below the CEJ and Soft Tissue Height (STH) (ICC: 0.44 and 0.54, respectively). CBCT showed lower agreement with histology, particularly for thin CBT (< 1 mm), with an ICC of 0.20, compared to 0.90 for US vs. histology. CBCT failed to identify crestal bone in 14 cases when the crestal bone was thin. Notably, CBCT results differed more from histological measurements than US in assessing B-CEJ and thin CBT.
conclusionUS demonstrated substantial potential as a transformative tool for periodontal diagnostics, exhibiting high agreement with histology in determining critical parameters. Compared to CBCT, US offered advantages, particularly in cases with thin crestal bone.
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