Evidence map›Paper›PMID 39799399›Full record

ArticleBiophysical journal2025

A Drosophila cardiac myosin increases jump muscle stretch activation and shortening deactivation.

Kaylyn M Bell, Alon T Brown, Sarah K Van Houten, Anna C Blice-Baum, William A Kronert, Amy K Loya, Jared Rafael T Camillo, Anthony Cammarato, David T Corr, Sanford I Bernstein and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaylyn M BellDepartment of Biological Sciences & Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York.
Alon T BrownDepartment of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York.
Sarah K Van HoutenDepartment of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York.
Anna C Blice-BaumDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
William A KronertDepartment of Biology, Molecular Biology Institute, Heart Institute, San Diego State University, San Diego, California.
Amy K LoyaDepartment of Electrical, Computer, and Biomedical Engineering Union College, Schenectady, New York.
Jared Rafael T CamilloDepartment of Biology, Molecular Biology Institute, Heart Institute, San Diego State University, San Diego, California.
Anthony CammaratoDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
David T CorrDepartment of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York; Center for Modeling, Simulation, and Imaging in Medicine, Rensselaer Polytechnic Institute, Troy, New York.
Sanford I BernsteinDepartment of Biology, Molecular Biology Institute, Heart Institute, San Diego State University, San Diego, California.
Douglas M SwankDepartment of Biological Sciences & Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York. Electronic address: swankd@rpi.edu.

Funding

Genetics and Molecular Biology of Striated Muscle MyosinR37GM032443 · NIGMS · SAN DIEGO STATE UNIVERSITY · PI Sanford I Bernstein · 2017 to 2026
$5.5M
PATHOGENESIS AND IN VIVO SUPPRESSION OF THIN FILAMENT-BASED CARDIOMYOPATHIESR01HL124091 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Anthony Cammarato · 2015 to 2026
$4.3M
New mechanisms behind skeletal muscle enduranceR01AR083916 · NIAMS · RENSSELAER POLYTECHNIC INSTITUTE · PI DOUGLAS M SWANK · 2025 to 2026
$1.0M
NHLBI NIH HHS R01 HL124091NIAMS NIH HHS R01 AR083916NIGMS NIH HHS R37 GM032443
6 · The paper itself

Abstract

Stretch activation (SA), a delayed increase in force production after rapid muscle lengthening, is critical to the function of vertebrate cardiac muscle and insect asynchronous indirect flight muscle. SA enables or increases power generation in muscle types used in a cyclical manner. Recently, myosin isoform expression has been implicated as a mechanism for varying the amplitude of SA in some muscle types. For instance, we found that expressing a larval Drosophila myosin isoform in a muscle type with minimal SA, the Drosophila jump muscle, substantially increased SA amplitude and enabled positive cyclical power generation. To test whether other myosin isoforms could increase SA amplitude and whether the Drosophila heart benefits from SA, we identified two Drosophila cardiac myosin isoforms, CardM1 and CardM2, and expressed them in Drosophila jump muscle. CardM1, CardM2, and control jump muscle fibers all displayed the characteristic phase 3 of SA, with CardM2 SA amplitude ∼60% greater than that of CardM1 and control fibers. Increasing [P

Indexed as

Cardiac MyosinsDrosophilaDrosophila melanogasterDrosophila ProteinsMuscle ContractionAnimalsBiomechanical PhenomenaProtein IsoformsCardiac MyosinsDrosophila ProteinsProtein Isoforms

Identifiers

PMID39799399
PMCPMC11900181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.