Evidence map›Paper›PMID 39799274›Full record

ArticleBritish journal of cancer2025

Sodium nitrite orchestrates macrophage mimicry of tongue squamous carcinoma cells to drive lymphatic metastasis.

Xiangwan Lu, Weifan Lin, Junheng Zheng, Wuheng Huang, Shuyi Yu, Haoxiang Chen, Hua Wang, Yan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiangwan LuMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Weifan LinMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Junheng ZhengMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Wuheng HuangMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Shuyi YuMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Haoxiang ChenMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Hua WangDepartment of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, PR China. wanghua9@mail.sysu.edu.cn.
Yan ZhangMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China. zhang39@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-3702-3401

Funding

China Postdoctoral Science Foundation 2023M744083Guangdong Science and Technology Department (Science and Technology Department, Guangdong Province) 2019B1515210015National Natural Science Foundation of China (National Science Foundation of China) 31871413Postdoctoral Research Foundation of China (China Postdoctoral Research Foundation) 2023M744083Shenzhen Science and Technology Innovation Commission KJZD20230923114802005
6 · The paper itself

Abstract

backgroundTongue squamous cell carcinoma (TSCC) is a malignant oral cancer with unclear pathogenesis that shows a tendency for early-stage lymphatic metastasis. This results in a poor prognosis, with a low 5-year survival rate. Dietary sodium nitrite (NaNO

methodsIn vitro and in vivo assays were used to investigate the role of NaNO

resultsThe data in this study showed that NaNO

conclusionsOur findings highlight the role of NaNO2 in enabling macrophage mimicry in TSCC cells through the CREB1-CD68 signaling pathway, which promotes lymphatic metastasis. Shedding light on drivers of lymphatic metastasis in TSCC and providing a new perspective on dietary strategies to improve outcomes of patients with TSCC.

Indexed as

Carcinoma, Squamous CellLymphatic MetastasisMacrophagesSodium NitriteSquamous Cell Carcinoma of Head and NeckTongue NeoplasmsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCell Line, TumorCell MovementCyclic AMP Response Element-Binding ProteinFemaleGene Expression Regulation, NeoplasticHumansAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 MoleculeCyclic AMP Response Element-Binding ProteinSodium Nitrite

Identifiers

PMID39799274
PMCPMC11833070

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.