ArticleScientific reports2025
The mediating role of inflammatory biomarkers in the association between serum copper and sarcopenia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Food-grade utilization of bovine slaughterhouse by-products for developing cost-effective media supplements in cultivated meat applications.Food science of animal resources · 2026Review
- Agricultural Copper Pesticide Exposure and Metabolic Profiles among Parkinson's Disease Cases and Community Controls in California.Chemical research in toxicology · 2026Article
- Concentration of Trace Elements in Patients with Aortic Stenosis and Coexisting Coronary Artery Disease: A Pilot Study.Journal of clinical medicine · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
This study aims to investigate the association between serum copper (Cu), selenium (Se), zinc (Zn), Se/Cu and Zn/Cu ratios and the risk of sarcopenia. In this study, which involved 2766 adults aged ≥ 20 years enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016, multivariable logistic regression, restricted cubic spline (RCS) models and mediation analyses were used. After full adjustment, multivariable logistic regression revealed that higher serum copper levels were correlated with an increased risk of sarcopenia. Conversely, higher serum Se/Cu (OR 0.45, 95% CI 0.23-0.89, P = 0.023) and Zn/Cu (OR 0.49, 95% CI 0.27-0.90, P = 0.024) were associated with a decreased risk of sarcopenia. The RCS curve indicated a non-linear, roughly inverted L-shaped relationship between serum Cu and sarcopenia risk (P non-linear < 0.001). Additionally, Se/Cu (P non-linear = 0.179) and Zn/Cu (P non-linear = 0.786) showed negative linear associations with sarcopenia risk. Furthermore, white blood cell (WBC) count, neutrophil count, and systemic inflammation index (SII) were identified as significant mediators in the relationship between serum Cu and the risk of sarcopenia, with mediation proportions of 6.34%, 6.20%, and 4.37%, respectively (all P < 0.05). Therefore, balancing essential trace metals is crucial for maintaining muscle health.
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