Evidence map›Paper›PMID 39799120›Full record

ArticleScientific data2025

BOston Neonatal Brain Injury Data for Hypoxic Ischemic Encephalopathy (BONBID-HIE): I. MRI and Lesion Labeling.

Rina Bao, Ya'nan Song, Sara V Bates, Rebecca J Weiss, Anna N Foster, Camilo Jaimes, Susan Sotardi, Yue Zhang, Randy L Hirschtick, P Ellen Grant and 1 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rina BaoBoston Children's Hospital, Boston, MA, USA. rina.bao@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-2367-2590
Ya'nan SongBoston Children's Hospital, Boston, MA, USA.
Sara V BatesHarvard Medical School, Boston, MA, USA.
Rebecca J WeissBoston Children's Hospital, Boston, MA, USA.
Anna N FosterBoston Children's Hospital, Boston, MA, USA.
Camilo JaimesHarvard Medical School, Boston, MA, USA.
Susan SotardiBoston Children's Hospital, Boston, MA, USA.
Yue ZhangBoston Children's Hospital, Boston, MA, USA.
Randy L Hirschtick *Harvard Medical School, Boston, MA, USA.
P Ellen Grant *Boston Children's Hospital, Boston, MA, USA.
Yangming Ou *Boston Children's Hospital, Boston, MA, USA. yangming.ou@childrens.harvard.edu.

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)R61NS126792 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI COTTEN, CHARLES MICHAEL, GRANT, PATRICIA ELLEN · 2022 to 2024
$2.7M
Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)R33NS126792 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI CHARLES Michael COTTEN, Patricia Ellen Grant · 2025 to 2026
$1.8M
Neural Substrate of Outcomes after Neonatal Hypoxic Ischemic EncephalopathyR21NS121735 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI OU, YANGMING · 2022 to 2023
$504k
Multi-Site Clinical Data to Power MRI Biomarker of Neonatal Brain InjuryR03HD104891 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI OU, YANGMING · 2021 to 2022
$190k
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R03HD104891Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R21NS121735Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R61NS126792NICHD NIH HHS P50 HD105351NICHD NIH HHS R03 HD104891NINDS NIH HHS R21 NS121735NINDS NIH HHS R33 NS126792NINDS NIH HHS R61 NS126792
6 · The paper itself

Abstract

Hypoxic ischemic encephalopathy (HIE) is a brain injury that occurs in 1 ~ 5/1000 term neonates. Accurate identification and segmentation of HIE-related lesions in neonatal brain magnetic resonance images (MRIs) is the first step toward identifying high-risk patients, understanding neurological symptoms, evaluating treatment effects, and predicting outcomes. We release the first public dataset containing neonatal brain diffusion MRI and expert annotation of lesions from 133 patients diagnosed with HIE. HIE-related lesions in brain MRI are often diffuse (i.e., multi-focal), and small (over half the patients in our data having lesions occupying <1% of the brain volume (including ventricles)). Segmentation for HIE MRI data is remarkably different from, and arguably more challenging than, other segmentation tasks such as brain tumors with focal and relatively large lesions. We hope that this dataset can help fuel the development of MRI lesion segmentation methods for HIE and small diffuse lesions in general.

Indexed as

Brain InjuriesHypoxia-Ischemia, BrainBrainHumansInfant, NewbornMagnetic Resonance Imaging

Identifiers

PMID39799120
PMCPMC11724925

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.