ArticleBritish journal of anaesthesia2025
Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity.
Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Under the Drapes: Unmasking the Mechanisms and Clinical Diagnosis of Perioperative Hypersensitivity.Current allergy and asthma reports · 2026Review
- Low-Dose Intravenous Challenge Testing to Neuromuscular Blocking Agents: A Safe and Effective Approach to the Investigation of Perioperative Anaphylaxis. Comment on Clin Exp Allergy 2026;56:438-441.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Peri-operative allergy: continuing to navigate uncertainty.Anaesthesia · 2026Article
- Drug-induced anaphylaxis: Molecular pathophysiology, diagnosis, and management.Asia Pacific allergy · 2026Article
- A case report: intravenous provocation testing clears rocuronium after sugammadex-rocuronium complex-induced anaphylaxis.BJA open · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuromuscular blocking agents are a common cause of perioperative hypersensitivity. The sensitivity and specificity of skin tests and in vitro tests in this context have not been determined conclusively, which poses a barrier to accurate diagnosis. Use of challenge testing represents a promising development in this field and a key tool in confirming tolerance to an alternate neuromuscular blocking agent for use in future anaesthesia. However, its use is currently limited to specialised centres, and a standardised approach to testing has not yet been established. This article summarises the role of challenge testing to neuromuscular blocking agents and highlights the advantages and disadvantages of the different approaches.
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