ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2025
Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function.
Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The role and application of task-state fNIRS in identifying biomarkers in children and adolescents with ADHD: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory.eLife · 2026Pooled it
- Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal-prefrontal synchrony.Nature neuroscience · 2026Article
- Developmental deviations of association-network structural connectivity in youths with ADHD predict symptom and treatment outcomes.Nature biomedical engineering · 2026Article
- When attention falters: Brain, breathing, and behavioral signals of lapses in interoceptive attention.Cognitive, affective & behavioral neuroscience · 2026Article
- Lonely individuals have a more negative perception of their bodies: The mediating role of self-cognition and social perception brain network connectivity.Cognitive, affective & behavioral neuroscience · 2026Article
- Spatial amyloid-informed multimodal brain age as an early marker of Alzheimer's-related vulnerability and risk stratification.The journal of prevention of Alzheimer's disease · 2026Article
- Global cortical arousal effects in fMRI reveal brain markers of state and trait anxiety.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Multimodal brain network disruption and structural-functional decoupling in overt hypothyroidism.Frontiers in endocrinology · 2026Article
- The role of coupling among brain regions between the default mode network and the "Mesocircuit" Model in arousal in disorders of consciousness.Frontiers in neurology · 2026Article
- Phenomenology of the stream of thought: dissociable dynamic dimensions revealed through experience sampling.Neuroscience of consciousness · 2026Article
- Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting.bioRxiv : the preprint server for biology · 2025Article
- Unlocking deep relaxation: the power of rhythmic breathing on brain rhythms.Npj mental health research · 2025Article
- Introduction to the Special Issue on Mindfulness: Measurement, Methods, Mechanisms, & Mental Health.Biological psychiatry global open science · 2025Article
- Introduction to the Special Issue on Cognitive Neuroscience of Mindfulness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Dynamic functional connectivity signatures of focused attention on the breath in adolescents.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Abnormal brain network reconfiguration in neuropsychiatric disorders across cognitive decline, Depression, and Schizophrenia.PloS one · 2025Article
- Examining recent effects of caffeine on default mode network and dorsal attention network anticorrelation in youth.PloS one · 2025Article
- Effects of rTMS over the contralateral M1 combined with NMES on pain and functional mobility in primary frozen shoulder: study protocol for a 4-week double-blind, randomized, sham-controlled trial.Frontiers in neurology · 2025Article
- The Interaction Effects of Sex, Age, APOE and Common Health Risk Factors on Human Brain Functions.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, goal-directed cognition, self-projection, and theory of mind. In recent years, there has been a surge in the number of studies examining its functional connectivity, particularly its relationship with frontoparietal networks involved in top-down attention, executive function, and cognitive control. The fluidity in switching between these internal and external modes of processing, which is highlighted by anticorrelated functional connectivity, has been proposed as an indicator of cognitive health. Due to the ease of estimation of functional connectivity-based measures through resting-state functional magnetic resonance imaging paradigms, there is now a wealth of large-scale datasets, paving the way for standardized connectivity benchmarks. In this review, we explore the promising role of DMN connectivity metrics as potential biomarkers of cognitive state across attention, internal mentation, mind wandering, and meditation states and investigate deviations in trait-level measures across aging and in clinical conditions such as Alzheimer's disease, Parkinson's disease, depression, attention-deficit/hyperactivity disorder, and others. We also tackle the issue of reliability of network estimation and functional connectivity and share recommendations for using functional connectivity measures as a biomarker of cognitive health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.