Evidence map›Paper›PMID 39798087›Full record

ArticleCell reports2025

Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors.

Ashley F George, Jason Neidleman, Xiaoyu Luo, Julie Frouard, Natalie Elphick, Kailin Yin, Kyrlia C Young, Tongcui Ma, Alicer K Andrew, Ifeanyi J Ezeonwumelu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ashley F GeorgeGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Jason NeidlemanGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Xiaoyu LuoGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Julie FrouardGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Natalie ElphickGladstone Institutes, San Francisco, CA, USA.
Kailin YinGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Kyrlia C YoungGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Tongcui MaGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Alicer K AndrewGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Ifeanyi J EzeonwumeluGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA.
Jesper G PedersenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Antoine ChaillonDivision of Infectious Diseases and Global Public Health, UCSD, La Jolla, CA, USA.
Magali PorrachiaDivision of Infectious Diseases and Global Public Health, UCSD, La Jolla, CA, USA.
Brendon WoodworthDivision of Infectious Diseases and Global Public Health, UCSD, La Jolla, CA, USA.
Martin R JakobsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Reuben ThomasGladstone Institutes, San Francisco, CA, USA.
Davey M SmithDivision of Infectious Diseases and Global Public Health, UCSD, La Jolla, CA, USA.
Sara GianellaDivision of Infectious Diseases and Global Public Health, UCSD, La Jolla, CA, USA.
Nadia R RoanGladstone Institutes, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA. Electronic address: nadia.roan@gladstone.ucsf.edu.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI164567 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2021 to 2026
$31.6M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Project-004P01AI169609 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 2022 to 2026
$10.6M
The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to reboundP01AI169606 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Steven A Yukl · 2022 to 2026
$9.3M
Project 3: Identifying plasma biomarkers predicting time to HIV rebound after treatment interruptionP01AI131374 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI PILLAI, SATISH KUMAR · 2017 to 2021
$8.5M
Phenotypic and mechanistic analysis of the in vivo HIV latent reservoir by single-cell technologiesR01AI147777 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2019 to 2022
$3.8M
Multiomics characterization, induction, and elimination of the HIV gut reservoirR01DK131526 · NIDDK · J. DAVID GLADSTONE INSTITUTES · PI Nancie Marie Archin, Nadia R Roan · 2022 to 2026
$3.7M
Targeting the transcriptionally-active reservoir to reduce chronic inflammation in aged people with HIVR01AI183286 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Melanie Maria Ott, Nadia R Roan · 2024 to 2026
$2.7M
NCRR NIH HHS S10 RR028962NIAID NIH HHS P01 AI131374NIAID NIH HHS P01 AI169606NIAID NIH HHS P01 AI169609NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI036214NIAID NIH HHS R00 AI104262NIAID NIH HHS R01 AI127219NIAID NIH HHS R01 AI147777NIAID NIH HHS R01 AI183286NIAID NIH HHS R21 AI122821NIAID NIH HHS R21 AI172060NIAID NIH HHS R21 AI184073NIAID NIH HHS T32 AI007334NIAID NIH HHS UM1 AI164559NIAID NIH HHS UM1 AI164567NICHD NIH HHS K99 HD110319NIDA NIH HHS DP2 DA051915NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK131526NIH HHS S10 OD018040
6 · The paper itself

Abstract

We developed viral sensor and restriction factor-cytometry by time of flight (VISOR-CyTOF), which profiles 19 viral sensors and restriction factors (VISORs) simultaneously in single cells, and applied it to 41 postmortem tissues from people with HIV. Mucosal myeloid cells are well equipped with SAMHD1 and sensors of viral capsid and DNA while CD4

Indexed as

Antiviral Restriction FactorsHIV-1HIV InfectionsCD4-Positive T-LymphocytesHumansMyeloid CellsSAM Domain and HD Domain-Containing Protein 1Virus LatencyVirus ReplicationAntiviral Restriction FactorsSAM Domain and HD Domain-Containing Protein 1CD4(+) T cellsCP: ImmunologyCyTOFHIV-1IFNmyeloid cellspostmortem tissuesSAMHD1viral sensing and restriction

Identifiers

PMID39798087
PMCPMC11829653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.