Evidence map›Paper›PMID 39798080›Full record

ArticleACS chemical neuroscience2025

Regulation of Dopamine Release by Tonic Activity Patterns in the Striatal Brain Slice.

Siham Boumhaouad, Emily A Makowicz, Sejoon Choi, Nezha Bouhaddou, Jihane Balla, Khalid Taghzouti, David Sulzer, Eugene V Mosharov

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Altered striatal dopamine regulation in Adgrl3 knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siham BoumhaouadDepartments of Psychiatry and Neurology, Division of Molecular Therapeutics, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York 10032, United States.
Emily A MakowiczDepartments of Psychiatry and Neurology, Division of Molecular Therapeutics, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York 10032, United States.
Sejoon ChoiDepartments of Psychiatry and Neurology, Division of Molecular Therapeutics, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York 10032, United States.
Nezha BouhaddouPhysiology and Physiopathology Team, Genomics of Human Pathologies Research Center, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10000, Morocco.
Jihane BallaPhysiology and Physiopathology Team, Genomics of Human Pathologies Research Center, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10000, Morocco.ORCID 0000-0002-6023-0508
Khalid TaghzoutiPhysiology and Physiopathology Team, Genomics of Human Pathologies Research Center, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10000, Morocco.
David SulzerDepartments of Psychiatry and Neurology, Division of Molecular Therapeutics, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York 10032, United States.
Eugene V MosharovDepartments of Psychiatry and Neurology, Division of Molecular Therapeutics, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York 10032, United States.ORCID 0000-0002-0229-7114

Funding

The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
ADVANCED GRADUATE TRAINING PROGRAM IN NEUROBIOLOGY & BEHAVIORT32NS064928 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENGST, ULRICH · 2010 to 2024
$3.0M
Neurobiology and Behavior training grantT32MH126036 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber · 2020 to 2026
$2.5M
NIDA NIH HHS R01 DA007418NIMH NIH HHS T32 MH126036NINDS NIH HHS T32 NS064928
6 · The paper itself

Abstract

Voluntary movement, motivation, and reinforcement learning depend on the activity of ventral midbrain neurons, which extend axons to release dopamine (DA) in the striatum. These neurons exhibit two patterns of action potential activity: low-frequency tonic activity that is intrinsically generated and superimposed high-frequency phasic bursts that are driven by synaptic inputs.

Indexed as

Action PotentialsCorpus StriatumDopamineNeuronsAnimalsDopamine D2 Receptor AntagonistsMaleRatsReceptors, Dopamine D2DopamineDopamine D2 Receptor AntagonistsReceptors, Dopamine D2D2 receptorsdopaminefast-scan cyclic voltammetryin vivo DA releasenicotinic acetylcholine receptorstriatal slice

Identifiers

PMID39798080
PMCPMC11804867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.