Evidence map›Paper›PMID 39798068›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Individualized morphological covariation network aberrance associated with seizure relapse after antiseizure medication withdrawal.

Ge Tan, Xiuli Li, Ping Jiang, Du Lei, Fangzhou Liu, Yingchun Xu, Bochao Cheng, Qiyong Gong, Ling Liu

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ge Tan *Epilepsy Center, Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0001-5257-8099
Xiuli Li *Department of Radiology and Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China.
Ping JiangResearch Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China.
Du LeiDepartment of Radiology and Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China.
Fangzhou LiuEpilepsy Center, Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Yingchun XuEpilepsy Center, Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Bochao ChengDepartment of Radiology, West China Second University Hospital of Sichuan University, Chengdu, China.
Qiyong GongDepartment of Radiology and Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China.
Ling LiuEpilepsy Center, Department of Neurology, West China Hospital of Sichuan University, Chengdu, China. neurologyliuling@163.com.ORCID http://orcid.org/0000-0001-7588-6086

Funding

the 1·3·5 projects for Artificial Intelligence, West China Hospital, Sichuan University ZYAI24032the Health Commission of Sichuan Province 21PJ032the National Key R&D Program 2022YFC2009900the National Natural Science Foundation of China 81621003the National Natural Science Foundation of China 81820108018the National Natural Science Foundation of China 82301640the Science and Technology Department of Sichuan Province 2022NSFSC1361the Science & Technology Department of Sichuan Province 2024YFHZ0057
6 · The paper itself

Abstract

This study intents to detect graphical network features associated with seizure relapse following antiseizure medication (ASM) withdrawal. Twenty-four patients remaining seizure-free (SF-group) and 22 experiencing seizure relapse (SR-group) following ASM withdrawal as well as 46 matched healthy participants (Control) were included. Individualized morphological similarity network was constructed using T1-weighted images, and graphic metrics were compared between groups. Relative to the Control, the SF-group exhibited lower local efficiency, while the SR-group displayed lower global and local efficiency and longer characteristic path length. Both patient groups displayed reduced centrality in certain subcortical and cortical nodes than the Control, with a more pronounced reduction in the SR-group. Additionally, the SR-group exhibited lower centrality of the right pallidum than the SF-group. Decreased subcortical-cortical connectivity was found in both patient groups than the Control, with a more extensive decrease in the SR-group. Furthermore, an edge connecting the right pallidum and left middle temporal gyrus exhibited decreased connectivity in the SR-group than in the SF-group. A weaker small-worldization network upon medication withdrawal, potentially underpinned by node decentralization and subcortical-cortical decoupling, may elevate the risk of seizure relapse.

Indexed as

AnticonvulsantsBrainNerve NetSeizuresAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRecurrenceYoung AdultAnticonvulsantsAntiseizure medication withdrawalEpilepsyGraph theoryMorphological covariation networkSeizure relapse

Identifiers

PMID39798068

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.