Trial reportRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025
Cognitive changes in post-stroke depression patients undergoing treatment with transcranial direct current stimulation (tDCS): an exploratory, ancillary analysis of a randomized, sham-controlled clinical trial.
Trial report in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of non-invasive brain stimulation for post-stroke depression: a systematic review and meta-analysis.Frontiers in psychology · 2026Pooled it
- The Therapeutic Potential of Mesenchymal Stem Cells in Post-Stroke Depression.International journal of molecular sciences · 2026Review
- Neuromodulation and rehabilitation of post-stroke cognitive impairment: challenges and prospects.Frontiers in psychiatry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivePost-stroke depression affects approximately 40% of stroke survivors, with cognitive deficits being frequently observed. Transcranial direct current stimulation (tDCS) has shown promise in improving cognitive performance in stroke patients. We explored the effects of tDCS on cognitive performance in post-stroke depression.
methodsWe conducted an exploratory analysis of 48 patients from a double-blinded, shamcontrolled, randomized clinical trial that investigated the effects of tDCS on post-stroke depression. A neuropsychological battery was applied at baseline and endpoint. We assessed three key domains: 1) the Stroop effect, measured with Stroop Test components (the color-naming, word-reading, and word-color interference tasks); 2) processing speed, measured with the Trail Making Test and the Digit Symbol-Coding task; 3) executive function, assessed with the Digit Span test and the Frontal Assessment Battery. Linear mixed regression models were used to evaluate group-wise changes.
resultsWe found that executive function worsened slightly in the active tDCS group and improved in the sham group in the adjusted models. Significant interactions were also found for the Frontal Assessment Battery.
conclusionsWe found no consistent evidence that tDCS significantly improved cognitive domains. The bidirectional association with cognition analysis suggests that the effects of tDCS may vary based on depression severity and task complexity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.