Evidence map›Paper›PMID 39797763›Full record

ArticleRNA (New York, N.Y.)2025

Thermodynamic control of mismatch discrimination for extensive splicing regulation of PKM pre-mRNA.

Natalia Bartyś, Jolanta Lisowiec-Wąchnicka, Anna Pasternak

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalia BartyśDepartment of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland nbartys@ibch.poznan.pl apa@ibch.poznan.pl.ORCID 0000-0001-5693-6199
Jolanta Lisowiec-WąchnickaDepartment of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.ORCID 0000-0002-3910-9682
Anna PasternakDepartment of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland nbartys@ibch.poznan.pl apa@ibch.poznan.pl.ORCID 0000-0002-9666-4148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, we present an approach to maximizing the splicing regulatory properties of splice-switching oligonucleotide (SSO) designed to regulate alternative splicing of pyruvate kinase M (

Indexed as

Alternative SplicingBase Pair MismatchPyruvate KinaseRNA PrecursorsCarrier ProteinsExonsHumansIntronsMembrane ProteinsOligonucleotidesRNA, MessengerRNA SplicingThermodynamicsThyroid Hormone-Binding ProteinsThyroid HormonesCarrier ProteinsMembrane ProteinsOligonucleotidesPyruvate KinaseRNA, MessengerRNA PrecursorsThyroid Hormone-Binding ProteinsThyroid Hormonesalternative splicingoligonucleotidesPKMsplicing regulation

Identifiers

PMID39797763
PMCPMC11912903

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.