Evidence map›Paper›PMID 39797761›Full record

ArticleGenes & development2025

Transcriptional regulation of the piRNA pathway by Ovo in animal ovarian germ cells.

Azad Alizada, Gregory J Hannon, Benjamin Czech Nicholson

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. In thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Azad AlizadaCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, United Kingdom.ORCID 0000-0002-2313-965X
Gregory J HannonCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, United Kingdom ben.nicholson@cruk.cam.ac.uk greg.hannon@cruk.cam.ac.uk.ORCID 0000-0003-4021-3898
Benjamin Czech NicholsonCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, United Kingdom ben.nicholson@cruk.cam.ac.uk greg.hannon@cruk.cam.ac.uk.ORCID 0000-0001-8471-0007

Funding

Wellcome Trust 110161Wellcome Trust 226627
6 · The paper itself

Abstract

The gene-regulatory mechanisms controlling the expression of the germline PIWI-interacting RNA (piRNA) pathway components within the gonads of metazoan species remain largely unexplored. In contrast to the male germline piRNA pathway, which in mice is known to be activated by the testis-specific transcription factor A-MYB, the nature of the ovary-specific gene-regulatory network driving the female germline piRNA pathway remains a mystery. Here, using

Indexed as

Drosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalGerm CellsOvaryRNA, Small InterferingTranscription FactorsTranscription, GeneticAnimalsFemalePiwi-Interacting RNADrosophila ProteinsPiwi-Interacting RNARNA, Small InterferingTranscription Factorsgerm cellsoogenesispiRNAstranscriptional regulationtransposon silencing

Identifiers

PMID39797761
PMCPMC11789646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.