Evidence map›Paper›PMID 39796774›Full record

ReviewCancers2025

A Personalized Approach for Oligometastatic Prostate Cancer: Current Understanding and Future Directions.

Parissa Alerasool, Susu Zhou, Eric Miller, Jonathan Anker, Brandon Tsao, Natasha Kyprianou, Che-Kai Tsao

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Oligometastatic Prostate Cancer: Clues from an N-of-1.Journal of clinical medicine · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Parissa AlerasoolDepartment of Hematology-Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Susu ZhouDepartment of Medicine, Icahn School of Medicine at Mount Sinai (Morningside/West), New York, NY 10025, USA.
Eric MillerDepartment of Hematology-Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jonathan AnkerDepartment of Hematology-Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Brandon TsaoDepartment of Hematology-Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Natasha KyprianouDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-8713-3599
Che-Kai TsaoDepartment of Hematology-Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Funding

Treatment-Induced Phenotypic Reprogramming in Prostate CancerR01CA232574 · NCI · UNIVERSITY OF KENTUCKY · PI KYPRIANOU, NATASHA · 2019 to 2023
$2.2M
NCI NIH HHS R01 CA232574
6 · The paper itself

Abstract

Oligometastatic prostate cancer (OMPC) represents an intermediate state in the progression from localized disease to widespread metastasis when the radiographically significant sites are limited in number and location. With no clear consensus on a definition, its diagnostic significance and associated optimal therapeutic approach remain controversial, posing a significant challenge for clinicians. The current standard of care for metastatic disease is to start systemic therapy; however, active surveillance and targeted radiotherapy have become attractive options to mitigate the long-term effects of androgen deprivation therapy (ADT). Furthermore, evolving biomarker methodologies may further define optimal treatment selection. In this review, we summarize the current understanding that guides the treatment of OMPC, with a focus on how host response can be an important contributing factor. Evolving scientific understanding and clinical development will continue to shape the landscape of treatment strategies for this distinct disease state.

Indexed as

androgen deprivation therapycastration-resistant prostate cancerfocal therapymetastasis-directed therapyoligometastasisoligometastatic diseaseprostate cancerPSMA PET scanradical prostatectomystereotactic body radiotherapy

Identifiers

PMID39796774
PMCPMC11720581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.