Evidence map›Paper›PMID 39796699›Full record

ArticleCancers2024

Exploring the Link Between Obligate Anaerobe-Related Dysbiosis and Prostate Cancer Development: A Pilot Study.

Efthymios Ladoukakis, Tim Oliver, Mark Wilks, Emily F Lane, Frank Chinegwundoh, Greg Shaw, Belinda Nedjai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Efthymios LadoukakisWolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Tim OliverBarts Cancer Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6AU, UK.
Mark WilksBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.ORCID 0000-0002-2170-1944
Emily F LaneWolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0002-9286-5145
Frank ChinegwundohBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.ORCID 0000-0002-7466-7225
Greg ShawDivision of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.
Belinda NedjaiWolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

Funding

Barts and The London Charity Equipment Grant 486/1193Orchid Cancer Charity 1997-2006Orchid Cancer Charity 2024-2025
6 · The paper itself

Abstract

BACKGROUND/

objectivesSeveral independent studies have associated prostate cancer (PCa) with specific groups of bacteria, most of them reporting the presence of anaerobic or microaerophilic species such as

methodsBuilding on this, in this study, we analyzed 89 post-rectal examination urine samples, from men with prostate cancer attending the PROVENT trial, using 16S rDNA sequencing. Our investigation focused on the impact of six previously identified OA genera (

resultsOur analysis revealed a statistically significant association between

conclusionsThese findings suggest that OA-related dysbiosis may contribute to elevated PSA levels through prostate cell damage even before prostate cancer develops, possibly playing a role in chronic inflammation and the hypervascular changes seen in precancerous lesions. Future clinical trials with larger cohorts are needed to further evaluate the role of OA in prostate cancer development and progression.

Indexed as

anaerobic bacteriacircumcisionimmune deficiencyprostate cancer

Identifiers

PMID39796699
PMCPMC11720123

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.