Trial reportNutrients2025
High-Intensity Interval Training Reduces Liver Enzyme Levels and Improves MASLD-Related Biomarkers in Overweight/Obese Girls.
Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of weight loss interventions on liver-related health in children and adolescents with obesity: a systematic review and meta-analyses.International journal of obesity (2005) · 2026Pooled it
- Systematic Review: Does Exercise Training Influence Ghrelin Levels?International journal of molecular sciences · 2025Pooled it
- Time-efficient and beneficial strategy: low-volume high-intensity interval training for cardiometabolic health and body composition outcomes in children and adolescents with overweight or obesity-a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Cardiorespiratory and Hematological Responses to High-Intensity Interval Training in Adolescent Girls With Overweight or Obesity: A Randomized Controlled Trial.European journal of sport science · 2026Trial
- Eccentric Isokinetic Rehabilitation for Chronic Lateral Epicondylitis in Female Swimmers: A Randomized Controlled Trial of Bilateral Neuromuscular Adaptations and Functional Performance.Medicina (Kaunas, Lithuania) · 2026Trial
- Moderate-Intensity Intermittent Walking Improves Liver-Related Biomarkers and Reduces Inflammation in Postmenopausal Women With Obesity: A Randomized Controlled Study.European journal of sport science · 2026Trial
- Effects of High-Intensity Interval Training on Steroid Hormones and Psychological Outcomes in Healthy Male Adolescents: A Randomized Controlled Trial.Sports (Basel, Switzerland) · 2026Article
- A Randomized Controlled Trial Comparing High- and Moderate-Intensity Interval Walking on Hematological and Functional Markers in Postmenopausal Women with Obesity.Sports (Basel, Switzerland) · 2026Article
- Review
- Beyond "Move More": Combined Physical Activity and Sedentary Behavior Assessment in Individuals with MASLD from Southern Italy.Journal of clinical medicine · 2026Article
- Clinical and microbial correlates of response to lifestyle intervention in pediatric metabolic dysfunction-associated steatotic liver disease.Gut pathogens · 2026Article
- Acute Effects of Exercise on Metabolic, Inflammatory, and Immune Markers in Adolescent Girls with Normal Weight or Overweight/Obesity.Sports (Basel, Switzerland) · 2026Article
- Persistence of the hepatic benefits of high-intensity interval training (HIIT) during detraining despite body weight regain in mice.PloS one · 2026Article
- Pediatric MASLD in Severe Obesity: Current Clinical Perspectives on Diagnosis and Treatment.Journal of clinical medicine · 2025Review
- Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease.World journal of gastrointestinal pathophysiology · 2025Review
- The combined effects of Tabata training and cinnamon supplementation on metabolic changes and body composition in soldiers with overweight or obesity.Journal of the International Society of Sports Nutrition · 2025Article
- Diet and Lifestyle Interventions in Metabolic Dysfunction-Associated Fatty Liver Disease: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Two-Year Mediterranean Diet Intervention Improves Hepatic Health in MASLD Patients.Foods (Basel, Switzerland) · 2025Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesDespite the abundant body of evidence linking high-intensity interval training (HIIT) to cardiometabolic markers, little is known about how HIIT affects liver enzymes, particularly in obese adolescents. This study aimed to investigate the effects of HIIT on metabolic dysfunction-associated steatotic liver disease (MASLD)-related biomarkers in overweight/obese adolescent girls.
methodsThirty-three overweight/obese adolescent girls (age, 17.0 ± 1.15 yr.; body mass index, 33.3 ± 4.77 kg/m
resultsSignificant "time × group" interactions were found for body composition indexes, systolic blood pressure, maximal aerobic speed, liver enzymes ALT and AST, plasma lipids, glucose, and HOMA-IR. The HIIT program resulted in an increase in maximal aerobic speed (
conclusionsHIIT resulted in an improvement in MASLD-related biomarkers. HIIT could be an effective exercise therapy to prevent and reverse MASLD in adolescents with obesity.
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