Evidence map›Paper›PMID 39796578›Full record

ArticleNutrients2024

Predictive Value of a Gastric Microbiota Dysbiosis Test for Stratifying Cancer Risk in Atrophic Gastritis Patients.

Alice Zaramella, Diletta Arcidiacono, Miriam Duci, Clara Benna, Salvatore Pucciarelli, Alberto Fantin, Antonio Rosato, Valli De Re, Renato Cannizzaro, Matteo Fassan and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Worldwide research trends on theFrontiers in immunology · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alice ZaramellaDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-5327-0325
Diletta ArcidiaconoGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy.ORCID 0000-0002-4417-6513
Miriam DuciDepartment of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
Clara BennaDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-9077-2471
Salvatore PucciarelliDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0001-5289-9925
Alberto FantinGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy.ORCID 0000-0002-7206-9117
Antonio RosatoDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy.
Valli De ReImmunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano, National Cancer Institute, IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-6100-9373
Renato CannizzaroOncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-2020-222X
Matteo FassanVeneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy.ORCID 0000-0001-6515-5482
Stefano RealdonOncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-6843-7637

Funding

Ricerca Corrente Istituto Oncologico Veneto (CRO-IRCCS) 2021-2022 (CRO-IRCCS) 2021-2022Ricerca Corrente Istituto Oncologico Veneto (IOV-IRCCS) 2018-2021 (IOV-IRCCS) 2018-2021Ricerca Finalizzata Grant number RF-2016-02363566
6 · The paper itself

Abstract

BACKGROUND/

objectivesGastric cancer (GC) incidence remains high worldwide, and the survival rate is poor. GC develops from atrophic gastritis (AG), associated with

methodsConsecutive patients undergoing upper endoscopy within an endoscopic follow-up for AG were considered. The antrum and corpus biopsies were used to assess the microbiota composition along the disease progression by sequencing the 16S ribosomal RNA gene. Statistical differences between HGD/GC and AG patients were included in a multivariate analysis.

resultsHGD/GC patients had a higher percentage of

conclusionsThe microbiome-based risk prediction model for GC could clarify the role of gastric microbiota as a cancer risk biomarker to be used in clinical practice. The proposed test might be used to personalize follow-up program thanks to a better cancer risk stratification.

Indexed as

DysbiosisGastritis, AtrophicGastrointestinal MicrobiomeStomach NeoplasmsAdultAgedDisease ProgressionFemaleHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedPredictive Value of TestsRisk AssessmentRisk FactorsRNA, Ribosomal, 16Sgastric cancerHelicobacter pylorimicrobiome

Identifiers

PMID39796578
PMCPMC11722812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.