Evidence map›Paper›PMID 39796563›Full record

ArticleNutrients2024

Clinical Presentations of Celiac Disease: Experience of a Single Italian Center.

Chiara Maria Trovato, Francesca Ferretti, Anna Pia Delli Bovi, Giovanna Elefante, Monica Ancinelli, Giulia Bolasco, Teresa Capriati, Sabrina Cardile, Daniela Knafelz, Fiammetta Bracci and 5 more

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chiara Maria TrovatoNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.ORCID 0000-0003-3869-1815
Francesca FerrettiNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Anna Pia Delli BoviClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy.
Giovanna ElefanteClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy.
Monica AncinelliNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Giulia BolascoNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Teresa CapriatiNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Sabrina CardileNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.ORCID 0000-0003-2912-3154
Daniela KnafelzNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Fiammetta BracciNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Arianna AlterioNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Monica MalamisuraGastroenterology and Nutrition Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Salvatore GrossoClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy.
Paola De AngelisGastroenterology and Nutrition Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.
Antonella DiamantiNutritional Rehabilitation Unit, Bambino Gesù Children Hospital IRCCS, 00165 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesIn Italy, the prevalence of celiac disease (CeD) among children exceeds 1.5% and has steadily increased with a linear trend over the past 25 years. The clinical presentation is heterogenous and a change in onset symptoms has been described in recent years. The aim of the study is to describe the pattern of clinical presentation of CeD during the last 12 years in a single Italian center.

methodsWe retrospectively enrolled all children diagnosed with CeD at Bambino Gesù Children Hospital, Rome between 1 March 2011 and 22 June 2023. To investigate the changes in pattern of clinical presentation, we divided the patient population into three groups of approximately 4 years each (respectively: 49, 48 and 48 months). Patients who previously received a CeD diagnosis in other centers were excluded.

resultsOverall, 4478 patients were diagnosed with CeD at our center. 1082 were excluded, leaving 3396 available for analysis. We divided the study cohort into three groups: group 1 (

conclusionsAnnual diagnoses of CeD increased during the study period, and the clinical presentation has changed in recent years, showing an increase in the non-classic form and a reduction in more severe forms of celiac crisis.

Indexed as

Celiac DiseaseAbdominal PainAdolescentChildChild, PreschoolFemaleHumansInfantItalyMalePrevalenceRetrospective Studiesautoimmune diseaseceliac diseaseclinical presentationdiagnosisgastrointestinal symptomsglutenItalyprevalence

Identifiers

PMID39796563
PMCPMC11723102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.