Evidence map›Paper›PMID 39796511›Full record

ArticleNutrients2024

Effect of a Novel Lavender Extract on Plasma Lipid and Lipoprotein Metabolism, Glucose Tolerance and Adipose Tissue Metabolic Activation: A Preclinical Safety and Efficacy Study.

Georgia Kakafoni, Evangelia Zvintzou, Smaro Kyroglou, Katerina Giannatou, Victoria Mparnia, Patroklos Vareltzis, Kyriakos E Kypreos

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dietary Supplementation withAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georgia KakafoniPharmacology Laboratory, Department of Medicine, University of Patras, 26500 Rio Achaia, Greece.
Evangelia ZvintzouPharmacology Laboratory, Department of Medicine, University of Patras, 26500 Rio Achaia, Greece.
Smaro KyroglouLaboratory of Food and Agricultural Industries Technologies, Chemical Engineering Department, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-4590-2652
Katerina GiannatouPharmacology Laboratory, Department of Medicine, University of Patras, 26500 Rio Achaia, Greece.
Victoria MparniaPharmacology Laboratory, Department of Medicine, University of Patras, 26500 Rio Achaia, Greece.
Patroklos VareltzisLaboratory of Food and Agricultural Industries Technologies, Chemical Engineering Department, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-4796-183X
Kyriakos E KypreosPharmacology Laboratory, Department of Medicine, University of Patras, 26500 Rio Achaia, Greece.ORCID 0000-0001-6784-2710

Funding

Hellenic Ministry of Agriculture, Program for Agricultural Development, ESPA 2014-2020, Submeasure 16.1 and 16.2 Μ16ΣΥΝ-00110
6 · The paper itself

Abstract

BACKGROUND/

objectivesLavender has been utilized for its medicinal properties since ancient times, with numerous health benefits reported. This study aimed to valorize solid waste from lavender essential oil production by developing a novel lavender extract from solid lavender residues. The extract's preclinical safety and efficacy were evaluated with emphasis on plasma lipid and lipoprotein metabolism, glucose tolerance, and adipose tissue metabolic activity.

methodsMale C57BL/6 mice were divided into four groups of five mice each and fed for 30 days with lavender extract encapsulated in 10% maltodextrin, mixed with a standard chow diet. The first group (Lav 1×) received 21.1 mg/kg/day, the second group (Lav 10×) received 211 mg/kg/day, and the third group (Lav 100×) received 2110 mg/kg/day. A placebo group consumed the standard diet without lavender extract. Key outcomes included plasma lipid and lipoprotein profiles, transaminase levels, HDL antioxidant and anti-inflammatory potential, glucose tolerance, and mitochondrial activity in white (WAT) and brown (BAT) adipose tissues.

resultsThe novel lavender extract induced dose-dependent improvements in lipid and lipoprotein metabolism, glucose tolerance, and adipose tissue activity. The 2110 mg/kg dose (100×) demonstrated the most significant beneficial effects, although it was associated with a slight elevation in hepatic transaminase levels, indicating potential mild hepatic stress.

Indexed as

Adipose TissueBlood GlucoseLavandulaLipid MetabolismLipidsLipoproteinsOils, VolatilePlant ExtractsAdipose Tissue, WhiteAnimalsMaleMiceMice, Inbred C57BLPlant OilsBlood GlucoseLipidsLipoproteinsOils, VolatilePlant ExtractsPlant Oilsbrown adipose tissuecircular economyefficacyglucose homeostasisLavandula stoechaslavenderlavender solid wastelipoproteinsmitochondrial metabolic activationsafetywhite adipose tissue

Identifiers

PMID39796511
PMCPMC11722746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.